VPC285785 is a potent inhibitor of the SARS-CoV-2 main protease, exhibiting an IC50 of 0.8 μM and a Kd of 2.7 μM. This compound effectively disrupts the processing of viral polyprotein precursors, which is crucial for viral replication. In studies with MHV-infected mice, VPC285785 significantly lowered viral loads in the liver, brain, and spleen. This reagent is valuable for research focused on coronavirus infections and therapeutic development.
VPC285785 is a potent inhibitor of the SARS-CoV-2 main protease, exhibiting an IC50 of 0.8 μM and a Kd of 2.7 μM. This compound effectively disrupts the processing of viral polyprotein precursors, which is crucial for viral replication. In studies with MHV-infected mice, VPC285785 significantly lowered viral loads in the liver, brain, and spleen. This reagent is valuable for research focused on coronavirus infections and therapeutic development.
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