Antiviral agent 25 is a novel non-peptide analog that functions as a covalent inhibitor of SARS-CoV-2 3CLpro and PLpro. It demonstrates potent inhibitory activity against these proteases, with IC50 values of 0.118 µM and 0.448 µM, respectively. Additionally, antiviral agent 25 exhibits effective antiviral activity against SARS-CoV-2, showing an EC50 value of 7.249 µM. This compound is valuable for research on viral replication and inhibition in SARS-CoV-2 studies.
Antiviral agent 25 is a novel non-peptide analog that functions as a covalent inhibitor of SARS-CoV-2 3CLpro and PLpro. It demonstrates potent inhibitory activity against these proteases, with IC50 values of 0.118 µM and 0.448 µM, respectively. Additionally, antiviral agent 25 exhibits effective antiviral activity against SARS-CoV-2, showing an EC50 value of 7.249 µM. This compound is valuable for research on viral replication and inhibition in SARS-CoV-2 studies.
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