TKB272 is a selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively inhibits the infection and replication of various SARS-CoV-2 strains, including Omicron variants, with an IC50 of 0.7 µM and an EC50 as low as 2.6 nM in cellular assays. Additionally, TKB272 demonstrates a high safety profile with a CC50 of 98 µM, indicating minimal cytotoxicity. Its ability to significantly reduce replication in transgenic mouse models highlights its potential as a valuable tool for SARS-CoV-2 research.
TKB272 is a selective antiviral agent targeting the main protease (Mpro) of SARS-CoV-2. It effectively inhibits the infection and replication of various SARS-CoV-2 strains, including Omicron variants, with an IC50 of 0.7 µM and an EC50 as low as 2.6 nM in cellular assays. Additionally, TKB272 demonstrates a high safety profile with a CC50 of 98 µM, indicating minimal cytotoxicity. Its ability to significantly reduce replication in transgenic mouse models highlights its potential as a valuable tool for SARS-CoV-2 research.
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