MWAC-3429 is a potent inhibitor of the SARS-CoV-2 Nsp13 helicase, demonstrating robust antiviral activity against both SARS-CoV-2 and SARS-CoV-1. With EC50 values of 5.39 μM (nLuc assay) and 17.00 μM (CPE assay), MWAC-3429 exhibits low cytotoxicity in A549-hACE2 cells, with a CC50 greater than 50 μM. This compound is valuable for research into SARS-CoV infections and the mechanistic understanding of viral helicase inhibition.
MWAC-3429 is a potent inhibitor of the SARS-CoV-2 Nsp13 helicase, demonstrating robust antiviral activity against both SARS-CoV-2 and SARS-CoV-1. With EC50 values of 5.39 μM (nLuc assay) and 17.00 μM (CPE assay), MWAC-3429 exhibits low cytotoxicity in A549-hACE2 cells, with a CC50 greater than 50 μM. This compound is valuable for research into SARS-CoV infections and the mechanistic understanding of viral helicase inhibition.
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