Fig. 1 · Structure
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N-Boc-4-pentyne-1-amine
PROTAC Linker
N-Boc-4-pentyne-1-amine is a PROTAC linker characterized by its alkyl chain composition. It is utilized in the synthesis of various PROTACs, including MG-277. As a click chemistry reagent, this compound features an alkyne group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with azide-containing molecules, facilitating targeted protein degradation studies and other biological research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 151978-50-6 |
| Applications | PROTAC Linker |
| Formula | C10H17NO2 |
| Molecular Weight | 183.25 |
| SMILES | O=C(OC(C)(C)C)NCCCC#C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.