Fig. 1 · Structure
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t-Boc-Aminooxy-PEG4-NHS ester
PROTAC Linkers
t-Boc-Aminooxy-PEG4-NHS ester is a PEG-based PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound features an aminooxy functional group and a NHS ester, allowing for efficient conjugation to target proteins. Its primary application lies in the development of innovative therapeutic strategies aimed at selective protein degradation, enhancing research in targeted protein modulation and cancer therapeutics.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2401831-99-8 |
| Applications | PROTAC Linkers |
| Formula | C20H34N2O11 |
| Molecular Weight | 478.49 |
| SMILES | O=C(OC(C)(C)C)NOCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.