Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
N1-Methylpentane-1,5-diamine serves as a versatile linker for PROTAC (Proteolysis Targeting Chimera) synthesis. Its unique structural properties facilitate the conjugation of target proteins to E3 ubiquitin ligases, enabling targeted protein degradation. This compound is instrumental in the design and development of novel biopharmaceuticals, enhancing research in protein modulation therapies. -
PROTAC Linker
rel-(3S,4S)-1-(tert-Butoxycarbonyl)-3-fluoropiperidine-4-carboxylic acid serves as a valuable PROTAC linker facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation to protein ligands, enhancing the specificity and efficacy of targeted protein degradation. Researchers can utilize this linker in the synthesis of novel PROTACs for various applications in drug discovery and therapeutic development. -
PROTAC Linker
Azide-PEG12-Tos is a PEG-based linker designed for use in PROTAC synthesis. This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition reactions (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds. Azide-PEG12-Tos is valuable for researchers working on targeted protein degradation and other bioconjugation applications. -
PROTAC Linker
4-(Boc-NH-Me)-(trans)-Cyclohexane-OH is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins by linking ligands that bind to the target and an E3 ligase, thereby enhancing the efficiency of targeted protein modulation. It is a crucial reagent for researchers investigating protein regulation and therapeutic strategies in cancer and other diseases. -
PROTAC Linker
13-(Benzyloxy)-13-oxotridecanoic acid serves as a PROTAC linker, facilitating the development of targeted protein degradation molecules. This compound is integral in the synthesis of PROTACs, which harness the ubiquitin-proteasome system to selectively degrade specific proteins within cellular contexts. Its unique structural properties enable efficient conjugation to bifunctional compounds, aiding in the exploration of therapeutic strategies in cancer and other diseases. -
PROTAC Linker
tert-Butyl 4-(4-aminophenyl)piperazine-1-carboxylate hydrochloride is a valuable PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it an essential tool in drug discovery and development. Its unique structure allows for the effective conjugation of target-binding ligands, advancing research in targeted protein degradation. -
PROTAC Linker
Methanamine-PEG4-methanamine is a versatile PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficiency of targeted protein degradation by providing optimal spacer flexibility and solubility. It is particularly useful for researchers focused on the design and synthesis of novel therapeutics that leverage the cellular degradation pathways for protein modulation. -
PROTAC Linker
(S,R.S)-AHPC-PEG8-acid is a synthetic linker designed for use in PROTAC (proteolysis-targeting chimera) research. Featuring an E3 ligase ligand fused to an eight-unit polyethylene glycol (PEG8) spacer, this compound enhances solubility in aqueous solutions. The carboxylic acid functionality is reactive towards amine-containing molecules, facilitating the construction of targeted protein degradation systems for drug discovery applications. - Tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]propanoate
PROTAC Linker
Tert-butyl 3-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,6-dihydro-2H-pyridin-1-yl]propanoate serves as a key PROTAC linker, facilitating the development of targeted protein degradation systems. This compound enhances the efficacy of bifunctional molecules by promoting the selective degradation of specific proteins. Its application is instrumental in research areas focused on drug discovery and the modulation of cellular pathways. -
PROTAC Linker
1,4-Butanedithiol is a versatile PROTAC linker that facilitates the synthesis of PROTAC molecules. This compound enhances the development of targeted protein degradation strategies by providing a robust link between E3 ligases and target proteins. It is primarily utilized in research applications focused on protein modulation and therapeutic development. -
PROTAC Linker
tert-Butyl 4-(2-ethoxy-1,1-difluoro-2-oxoethyl)piperidine-1-carboxylate serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound is essential for connecting the E3 ligase and target proteins, enabling selective degradation of intracellular proteins. Its unique structure allows for optimal binding and improved cellular activity, making it a valuable tool in drug discovery and protein modulation studies. -
PROTAC Linker
4-((4-Aminopiperidin-1-yl)methyl)benzonitrile hydrochloride is an innovative PROTAC linker designed to facilitate the synthesis of Proteolysis Targeting Chimeras (PROTACs). It serves as a critical component in the assembly of these bifunctional molecules, enabling targeted protein degradation with high specificity. This compound is extensively utilized in drug discovery and development, particularly in the field of targeted therapies for various diseases, including cancer. -
PROTAC Linker
Ts-PEG3-O-C-alkynes-TBS is a linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of target proteins to the ubiquitin-proteasome system, enabling selective protein degradation. It serves as a pivotal component in PROTAC development, enhancing the efficacy of targeted protein modulation for various research applications, including cancer biology and therapeutic discovery. -
PROTAC Linker
7-Aminoheptanoic acid hydrochloride is a versatile PROTAC linker that facilitates the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in studying protein degradation pathways and offers significant potential for targeted protein modulation in various therapeutic areas. Its application is essential in advancing research related to targeted therapies and drug development. -
PROTAC Linker
7-Bromoheptanoyl chloride serves as a chemical linker for the development of PROTAC (Proteolysis Targeting Chimera) agents, specifically in the synthesis of EGFR degrader 9. This compound facilitates targeted protein degradation by connecting the ligand to the E3 ligase, enabling the selective ubiquitination of the target protein. Its application in PROTAC technology supports advancements in therapeutic strategies against diseases associated with epidermal growth factor receptor (EGFR) dysregulation. -
PROTAC Linker
1-(2-Bromoethyl)piperazine serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound plays a pivotal role in the development of targeted protein degradation strategies, enabling researchers to employ ubiquitin-proteasome systems for selective protein modulation. Its utilization in research applications underscores its significance in exploring therapeutic avenues for various diseases through improved protein control. -
PROTAC Linker
N1,N4-dimethylcyclohexane-1,4-diamine is a key linker used in the development of PROTACs (proteolysis-targeting chimeras). This compound facilitates the recruitment of E3 ubiquitin ligases, thereby promoting the targeted degradation of specific proteins. Its utility extends to applications in cellular assays and drug discovery, enabling enhanced studies of protein interaction and degradation pathways. -
PROTAC Linker
N-(m-PEG4)-N'-(hydroxy-PEG2)-Cy5 is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates selective degradation of target proteins through its ability to connect E3 ligases with the protein of interest. Its unique structure enhances solubility and biocompatibility, making it suitable for a variety of research applications in targeted protein degradation studies. -
PROTAC Linker
tert-Butyl ((3-aminocyclobutyl)methyl)(methyl)carbamate serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound enables the targeted degradation of specific proteins by linking ligands to an E3 ligase. Its application in research focuses on studying protein turnover, modulating cellular pathways, and exploring potential therapeutic strategies in various diseases. -
PROTAC Linker
4-(2-Aminoethyl)cyclohexan-1-amine is a versatile PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of stable covalent bonds between target proteins and E3 ligases, enabling targeted protein degradation. Its application in chemical biology research supports the development of innovative therapeutics aimed at selectively modulating protein levels in various disease contexts. -
PROTAC Linker
Boc-Octahydrocyclopenta[c]pyrrole-amino is a specialized linker used in the development of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the targeted degradation of specific proteins by linking a ligand to an E3 ligase, enhancing the efficacy of protein modulation in research applications. Its unique structure allows for increased versatility and optimization in PROTAC synthesis. -
PROTAC Linker
4-(2-Chloroethoxy)benzaldehyde is a molecular linker designed for the synthesis of PROTAC (proteolysis-targeting chimera) compounds. It serves as an important component in the construction of PROTACs that facilitate targeted protein degradation. This compound is essential for advancing research in drug discovery and the development of innovative therapeutic strategies by selectively modulating protein levels within cells. -
PROTAC Linker
Di-tert-butyl adipate is a linker specifically utilized in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates the formation of bifunctional small molecules that promote targeted protein degradation. Its key applications include drug discovery and development, particularly in biochemistry and cellular biology research involving protein homeostasis and regulation. -
PROTAC Linker
tert-Butyl (2-(azetidin-3-yl)ethyl)carbamate is a synthetic linker designed for use in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the assembly of a target protein and an E3 ligase, promoting targeted protein degradation. Its application is crucial in the field of drug discovery for the study of protein function and regulation. -
PROTAC Linker
11-Hydroxyundecanoic acid serves as a PROTAC linker, playing a crucial role in the design and synthesis of protein-targeting chimeras. Its structural properties facilitate the effective conjugation of target proteins with E3 ligases, enhancing proteasome-mediated degradation pathways. This compound is valuable in research applications aimed at the development of targeted protein degradation strategies. -
PROTAC Linker
Boc-PEG3-I is a polyethylene glycol (PEG) based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands for target proteins, enhancing the degradation of selected substrates through the ubiquitin-proteasome system. Its application in PROTAC development allows researchers to harness targeted protein degradation for therapeutic purposes, making it an essential tool in drug discovery and development. -
PROTAC Linker
3-{[4-(Dihydroxyboranyl)phenyl]formamido}propanoic acid serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound plays a crucial role in synthesizing proteolysis-targeting chimeras (PROTACs), enhancing the delivery of E3 ligase-binding and target protein-binding moieties. Its unique structure allows for efficient assembly of PROTACs, making it valuable in chemical biology research and therapeutic development targeting disease-causing proteins. -
PROTAC Linker
tert-Butyl 2-(2-bromoethyl)-7-azaspiro[3.5]nonane-7-carboxylate functions as a PROTAC linker, facilitating the development of protein-targeting chimeras. This compound is instrumental in the synthesis of various PROTACs, offering potential for targeted protein degradation in therapeutic applications. Its unique structural properties enhance the efficiency and specificity of target ubiquitination, making it valuable for research in drug discovery and molecular biology. -
PROTAC Linker
15-Bromopentadecanoic acid serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting interactions between E3 ligases and ubiquitinated substrates. Its application is crucial in advancing research on targeted protein degradation and developing novel therapeutic strategies. -
PROTAC Linker
m-PEG16-Br is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (Proteolysis Targeting Chimeras) molecules. This compound facilitates targeted protein degradation by enabling the conjugation of E3 ligase and target proteins. Its prolonged hydrophilicity enhances solubility and bioavailability, making it a valuable tool for researchers studying protein dynamics and interactions in both cellular and molecular biology applications. -
PROTAC Linker
Thalidomide-O-PEG1-OH is a PROTAC linker that incorporates thalidomide, a ligand for E3 ligases that facilitates the ubiquitination and subsequent degradation of target proteins. The O-ethyl alcohol moiety serves as a versatile functional handle for further chemical modifications, enabling the synthesis of complex molecular architectures. This reagent is ideal for research involving targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
tert-Butyl N-(3-[(3-aminopropyl)(methyl)amino]propyl)carbamate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for creating bifunctional molecules that can selectively target and degrade specific proteins, making it invaluable for research in targeted protein degradation and related therapeutic applications. Its structural properties aid in the efficient conjugation of targeting and ubiquitination motifs necessary for effective PROTAC assembly. -
PROTAC Linker
Henicosanedioic acid is a PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for creating efficient molecular tools aimed at targeted protein degradation. Its structural properties enhance the connectivity and stability of PROTACs, enabling advanced research in protein regulation and therapeutic applications. -
PROTAC Linker
2-(4-(2-Hydroxyethyl)piperazin-1-yl)acetic acid serves as a PROTAC linker, playing a crucial role in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins through the recruitment of E3 ligases, contributing to advancements in targeted protein modulation and drug discovery. It is essential for research in the fields of cellular biology and pharmacology. -
PROTAC Linker
tert-Butyl (trans-3-(aminomethyl)cyclobutyl)carbamate functions as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances targeted protein degradation by conjugating E3 ligase ligands and target proteins, thereby promoting targeted therapeutic applications in cancer research and beyond. Its distinct structure allows for improved selectivity and stability in the synthesis of novel PROTAC compounds. -
PROTAC Linker
11-Aminoundecan-1-ol is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). By enabling the selective degradation of target proteins, this compound plays a crucial role in targeted protein modulation and therapeutic development. It is widely utilized in drug discovery research, particularly in the study of protein interactions and cellular pathways. -
PROTAC Linker
Hex-5-yn-1-amine hydrochloride acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is essential for conjugating E3 ligase ligands with target proteins, thereby promoting targeted degradation pathways in cellular systems. Its use is pivotal in research applications focused on protein regulation and therapy development. -
PROTAC Linker
Benzyl (4-aminobutyl)carbamate is a PROTAC linker designed to facilitate the development of proteolysis-targeting chimeras (PROTACs). By providing a flexible and stable linkage, it enhances the effectiveness of target protein degradation in cellular environments. This compound is a valuable tool for researchers investigating protein regulation and degradation mechanisms in various biological contexts. Its application spans across drug discovery and the study of disease-related protein interactions. -
PROTAC Linker
tert-Butyl 2-(piperazin-1-yl)acetate hydrochloride serves as a PROTAC linker, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). This reagent is essential for the synthesis of PROTACs that engage the ubiquitin-proteasome system, enabling targeted protein degradation. Its utility extends to various research applications in drug discovery and cellular biology, particularly in studies focused on targeted therapeutics. -
PROTAC Linker
Tert-butyl (2-((2-aminoethyl)(methyl)amino)ethyl)carbamate serves as a versatile PROTAC linker, facilitating the design and synthesis of PROTAC molecules. This compound enables the development of targeted protein degradation strategies, enhancing the specificity and efficacy of therapeutic applications. Its ability to create stable linkages makes it a valuable tool in chemical biology research focused on protein modulation and degradation pathways. -
PROTAC Linker
Acid-PEG8-S-S-PEG8-acid is a polyethylene glycol (PEG)-based linker designed for use in proteolysis-targeting chimeras (PROTACs). This bifunctional linker facilitates the conjugation of ligands to E3 ligases, enabling selective degradation of target proteins. It is particularly valuable in chemical biology research focused on targeted protein degradation and the development of innovative therapeutic strategies. -
PROTAC Linker
PEG1-bis(4,4,5,5-tetramethyl-2-phenyl-1,3,2-dioxaborolane) is an efficient PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins by recruiting E3 ligases, enabling the modulation of protein levels for therapeutic purposes. Its unique structure enhances solubility and stability, making it suitable for various biochemical applications, including drug development and target validation studies. -
PROTAC Linker
cis-Ethyl 2-(4-aminocyclohexyl)acetate hydrochloride is a versatile PROTAC linker designed to facilitate the synthesis of proteolysis-targeting chimeras (PROTACs). Its structural properties enhance the selective targeting and degradation of specific proteins, thereby providing valuable insight into protein function and cellular pathways. This compound is essential for researchers investigating targeted protein degradation strategies in therapeutic applications. -
PROTAC Linker
BnO-PEG2-Br is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins with E3 ligase, enabling the modulation of protein degradation pathways. Its application in drug discovery allows for the targeted degradation of specific proteins, presenting opportunities for innovative therapeutic strategies in cancer and other diseases. -
PROTAC Linker
13-((tert-Butoxycarbonyl)amino)tridecanoic acid is a versatile PROTAC linker utilized in the construction of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ubiquitin ligases to target proteins, promoting their degradation in cellular contexts. It represents a valuable tool for researchers investigating targeted protein degradation and associated pathways in chemical biology. -
PROTAC Linker
Propargyl-PEG1-NH2 hydrochloride is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of specific ligands to target proteins, enabling targeted degradation and modulation of protein function. Its versatile structure supports various applications in chemical biology and drug development, particularly in the study of protein homeostasis and targeted therapeutics. -
PROTAC Linker
2-(but-3-yn-1-yloxy)ethan-1-amine serves as a versatile PROTAC linker, facilitating the construction of proteolysis-targeting chimeras (PROTACs) for targeted protein degradation studies. This compound exhibits key biological activity by enabling the selective recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent proteosomal degradation. Its utility extends to research applications in drug discovery, biomarker validation, and elucidation of protein function. -
PROTAC Linker
tert-Butyl 4-(piperazin-1-yl)piperidine-1-carboxylate dihydrochloride is a specialized linker designed for use in the development of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to E3 ligases, thereby enhancing targeted protein degradation. Its application in PROTAC synthesis supports research in drug discovery, particularly for therapeutic interventions involving protein modulation. -
PROTAC Linker
Pentane-1,5-dithiol serves as a versatile PROTAC linker, facilitating the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by linking E3 ubiquitin ligases to the protein of interest, promoting targeted protein downregulation. Its application is crucial in studies focusing on protein clearance mechanisms and therapeutic strategies aimed at modulating protein levels within cellular environments. -
PROTAC Linker
NH2-bicyclo[1.1.1]pentane-C-OH hydrochloride serves as a potent linker for PROTAC (Proteolysis Targeting Chimera) development. This compound facilitates the creation of bifunctional molecules that engage E3 ubiquitin ligases for targeted protein degradation. Its application is critical in exploring protein regulation mechanisms and developing novel therapeutic strategies in cancer and other diseases.
