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CRBN ligand-258

Ligand for E3 Ligase

CRBN ligand-258 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of cereblon to target proteins, enabling the formation of targeted protein degradation chimeras (PROTACs) when linked with an appropriate target ligand. It serves as a valuable tool in drug discovery and development by promoting the ubiquitin-proteasome pathway for selective protein degradation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925091-71-8
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀BrN₃O₂
Molecular Weight	320.15
SMILES	O=C1NC(=O)CCN1C2=CC=C3C=CC(Br)=NC3=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.