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CRBN ligand-408

Ligand for E3 Ligase

CRBN ligand-408 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound is pivotal for the development of proteolysis-targeting chimeras (PROTACs) by linking target protein ligands through a suitable linker. It is useful in studying the modulation of protein degradation pathways and exploring the therapeutic potential of targeted protein degradation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2152673-38-4
Applications	Ligand for E3 Ligase
Formula	C₁₆H₁₉NO₅
Molecular Weight	305.33
SMILES	O=C(OC(C)(C)C)N1C(=O)CCC(C1=O)C2=CC=C(O)C=C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.