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CRBN ligand-641

Ligand for E3 Ligase

CRBN ligand-641 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), known for its role in targeted protein degradation. This compound facilitates the recruitment of CRBN to target proteins when conjugated with a suitable ligand through a linker, enabling the development of PROTACs. Its applications span drug discovery and therapeutic development, particularly in cancer research and the modulation of protein levels within cellular pathways.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925074-15-1
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₀N₄O₄
Molecular Weight	274.24
SMILES	O=C(O)C1=CC=2C=NNC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.