Fig. 1 · Structure
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CRBN ligand-705
Ligand for E3 Ligase
CRBN ligand-705 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the CRBN protein and can be utilized to create peptide-hybrid PROTACs when linked to a target protein ligand through a suitable linker. Its application in protein degradation research provides valuable insights into targeted protein modulation and therapeutic development.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Ligand / Binder |
| CAS Number | 2154357-70-5 |
| Applications | Ligand for E3 Ligase |
| Formula | C12H8ClN3O4 |
| Molecular Weight | 293.66 |
| SMILES | O=C1C=2C=CN=C(Cl)C2C(=O)N1C3C(=O)NC(=O)CC3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.