Catalog No.
Product Name
Application
Product Information
Citations
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Ligand for E3 Ligase
CRBN ligand-420 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound is designed for use in the development of proteolysis-targeting chimeras (PROTACs), enabling targeted degradation of specific proteins through the ubiquitin-proteasome system. CRBN ligand-420 is valuable for applications in drug discovery and protein regulation studies. -
Ligands for E3 Ligase
CRBN ligand-110 serves as a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of PROTAC (Proteolysis Targeting Chimeras). Its integration into PROTAC designs allows for targeted degradation of specific proteins, making it a valuable tool in drug discovery and therapeutic research. This compound is instrumental in exploring novel approaches to modulate protein levels and activity in cellular systems. -
Ligand for E3 Ligase
CRBN ligand-514 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, allowing the formation of a PROTAC (proteolysis-targeting chimeras). CRBN ligand-514 is instrumental in the study of targeted protein degradation and therapeutic applications in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-573 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein to target proteins. This compound can be conjugated with a target protein ligand using a linker to create a PROTAC (proteolysis-targeting chimera), enabling selective degradation of specific proteins. CRBN ligand-573 is valuable for research in targeted protein degradation and cellular regulation studies. -
Ligands for E3 Ligase
CRBN ligand-63 is a ligand for the CRBN-type E3 ubiquitin ligase, functioning as a key component in the development of PROTAC (proteolysis-targeting chimeras). This compound facilitates targeted protein degradation by harnessing the cellular ubiquitin-proteasome system, offering valuable utility in research focused on protein regulation and therapeutic interventions. Its application extends to the study of cellular pathways and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-300 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be effectively conjugated to a target protein ligand using a linker to generate a Proteolysis Targeting Chimera (PROTAC). Its application is significant in studies focused on targeted protein degradation and pharmacological interventions in various biological systems. -
Ligand for E3 Ligase
CRBN ligand-276 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a critical component for the development of PROTACs (Proteolysis Targeting Chimeras), which are utilized to promote targeted protein degradation. Its applications are particularly relevant in studies focusing on protein regulation and cellular signaling pathways in various diseases. -
Ligand for E3 Ligase
CRBN ligand-707 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be effectively utilized to create proteolysis-targeting chimeras (PROTACs) by linking it to a target protein ligand through a suitable linker. Its applications are vital in research related to targeted protein degradation and the modulation of cellular pathways governed by ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-396 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular systems. This compound can be coupled with a ligand targeting a specific protein through a suitable linker to create a proteolysis-targeting chimera (PROTAC). It allows for targeted degradation of proteins, enabling nuanced investigations into protein function and regulation. Key applications include the study of ubiquitin-proteasome pathway mechanisms and protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-451 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. It can be conjugated to a target protein ligand through a linker, enabling the construction of PROTACs (proteolysis-targeting chimeras). This compound is instrumental in research applications aimed at elucidating protein regulation and degradation mechanisms within cellular contexts. -
Ligand for E3 Ligase
CRBN ligand-518 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It functions by recruiting cereblon to target proteins, facilitating their ubiquitination and subsequent degradation. This compound is utilized in research applications involving proteolysis-targeting chimeras (PROTACs), enabling the targeted degradation of specific proteins within cellular systems. -
Ligand for E3 Ligase
CRBN ligand-339 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. It can be utilized to construct PROTACs (Proteolysis Targeting Chimeras) when linked to a specific target protein ligand via a suitable linker. This compound plays a critical role in targeted protein degradation research, enabling studies on ubiquitination and protein turnover. -
E3 Ubiquitin Ligases Ligand
CRBN ligand-184 is a selective ligand for CRBN-type E3 ubiquitin ligases. This compound plays a crucial role in the development of proteolysis-targeting chimeras (PROTACs), including the synthesis of PROTAC AU-24118. Its ability to engage E3 ligases provides valuable tools for targeted protein degradation research and the investigation of cellular protein dynamics. -
Ligand for E3 Ligase
(S,R,S)-AHPC 2-OH hydrochloride is a ligand for the E3 ubiquitin ligase VHL, facilitating the recruitment of the VHL protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTACs for targeted protein degradation applications in chemical biology research. Its utility in studying ubiquitin-proteasome system pathways makes it a valuable tool for investigating protein regulation and degradation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-259 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the targeted recruitment of the CRBN protein. This compound can be utilized to construct Proteolysis Targeting Chimeras (PROTACs) by linking it to a target protein ligand via a suitable linker. CRBN ligand-259 is instrumental in studies aimed at modulating protein degradation pathways, providing insights into protein homeostasis and potential therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-639 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand using a linker to create a proteolysis-targeting chimera (PROTAC). CRBN ligand-639 is instrumental in elucidating ubiquitin-mediated protein degradation pathways and has applications in targeted protein degradation research. -
Ligand for E3 Ligase
CRBN ligand-685 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a crucial building block for the synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation pathways. Researchers can utilize CRBN ligand-685 in studies of protein turnover, cellular degradation mechanisms, and the development of novel therapeutic strategies. -
Ligand for E3 Ligase
Desamino lenalidomide-7-CO is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound serves as a crucial component in the development of PROTACs (proteolysis-targeting chimeras) by enabling the linkage to target protein ligands through a suitable linker. Its application in targeted protein degradation research underscores its significance in investigating cellular pathways and therapeutic strategies. -
Ligands for E3 Ligase
3-(5-Bromo-2-chlorophenyl)piperidine-2,6-dione is a ligand for the CRBN-type E3 ubiquitin ligase, enabling the development of PROTAC (proteolysis-targeting chimeras) for targeted protein degradation. This compound facilitates the recruitment of ubiquitin ligases to specific proteins, highlighting its utility in studies focused on protein regulation and degradation pathways. Its application in drug discovery aims to enhance therapeutic strategies by modulating the cellular levels of target proteins. -
Ligand for E3 Ligase
CRBN ligand-506 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. This compound is valuable for research in cellular signaling, ubiquitination pathways, and the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
Thalidomide-O-amido-PEG1-azide is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in cellular processes. This compound can be conjugated with a target protein ligand through a linking mechanism to create a proteolysis-targeting chimera (PROTAC). Its ability to modulate protein degradation pathways makes it a valuable tool for research in therapeutic applications and targeted protein degradation studies. -
Ligand for E3 Ligase
CRBN ligand-265 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this crucial protein. Its design enables the conjugation with target protein ligands through a linker, thereby allowing for the formation of PROTACs (proteolysis-targeting chimeras). This compound is valuable in studies focusing on targeted protein degradation and the modulation of specific cellular pathways. -
Thalidomide Analogue
Thalidomide-5-(C6-amine) is a thalidomide analogue functioning as a PROTAC building block, featuring an E3 ligase ligand with a terminal amine group. This amine group facilitates conjugation reactions with NHS ester groups or carboxylic acids in the presence of coupling agents such as EDC or HATU. Thalidomide-5-(C6-amine) is valuable in the development of bifunctional degraders, supporting research in targeted protein degradation and therapeutic interventions. -
Ligand for E3 Ligase
CRBN ligand-356 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be utilized in the development of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand through a suitable linker. Its key biological activity makes it valuable for research in targeted protein degradation and therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN ligand-565 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound enables the targeted recruitment of cereblon, facilitating the development of PROTACs through its connection to target protein ligands via a suitable linker. Its utility in research includes the study of targeted protein degradation pathways and the modulation of various biological processes mediated by ubiquitination. -
Ligand for E3 Ligase
CRBN ligand-434 acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated with a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), a novel tool for targeted protein degradation. Its utility in research applications includes investigating the mechanisms of targeted ubiquitination and exploring therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-322 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of the cereblon protein. This compound can be utilized to conjugate with a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimeras). It is valuable for studying protein degradation pathways and exploring targeted protein degradation strategies in chemical biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-576 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein in cellular contexts. This compound can be connected to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). Its design allows for targeted protein degradation, making it a valuable tool in chemical biology and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-193 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimera (PROTAC). It is instrumental in studies aiming to harness targeted protein degradation as a therapeutic strategy. The application of CRBN ligand-193 advances research in drug development and cellular regulation. -
Ligand for E3 Ligase
CRBN ligand-281 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to facilitate the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of PROTAC (Proteolysis Targeting Chimera) molecules. Due to its specific interaction with CRBN, CRBN ligand-281 is valuable for studying targeted protein degradation mechanisms and the role of ubiquitin-proteasome pathways in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-869 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of this protein for targeted protein degradation. This compound can be conjugated with a ligand specific to the target protein through a suitable linker to create a PROTAC (proteolysis-targeting chimera). CRBN ligand-869 is valuable for research applications in protein modulation and therapeutic discovery. -
Ligand for E3 Ligase
CRBN ligand-508 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). It is utilized in research applications involving targeted protein degradation and E3 ligase modulation. -
Ligand for E3 Ligase
CRBN ligand-426 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a proteolysis-targeting chimeric molecule (PROTAC). It is useful in studies related to targeted protein degradation and the modulation of cellular protein levels. -
Ligand for E3 Ligase
CRBN ligand-314 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN for targeted protein degradation. This compound can be combined with a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), a valuable tool in the study of protein function and turnover in cellular processes. Its applications include research on targeted therapy and novel drug development strategies in oncology and other disease areas. -
Ligand for E3 Ligase
CRBN ligand-429 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein for targeted protein degradation applications. This compound can be effectively conjugated to a target protein ligand using a linker, enabling the formation of PROTAC (proteolysis-targeting chimeras) molecules. It serves as a valuable tool in the study of targeted degradation pathways and has potential utility in therapeutic research focused on modulating protein levels within cellular systems. -
Ligands for E3 Ligase
CRBN ligand-164 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the ubiquitination of target proteins. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras), which harness the ubiquitin-proteasome system to selectively degrade proteins of interest. Its ability to induce targeted protein degradation makes CRBN ligand-164 valuable in drug discovery and therapeutic research. -
Ligand for E3 Ligase
CRBN ligand-221 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in protein degradation pathways. This compound can be conjugated to a target protein ligand through a linker, allowing for the development of proteolysis targeting chimeras (PROTACs). Its applications include targeted protein degradation studies and the exploration of novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-750 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound serves as a valuable tool for the development of PROTACs (Proteolysis Targeting Chimeras) by enabling the targeted degradation of specific proteins through ubiquitin-mediated pathways. Its application in chemical biology underscores its potential in elucidating protein function and developing innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-207 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in protein degradation pathways. This compound serves as a crucial element for developing PROTACs (Proteolysis Targeting Chimeras) by linking to target protein ligands through a suitable linker. Its ability to promote targeted protein degradation makes it a valuable tool in cellular and molecular biology research, particularly in studies focused on ubiquitin-mediated proteolysis and the modulation of protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-341 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (proteolysis-targeting chimera), enabling targeted protein degradation. Its utilization aids in studying protein homeostasis and the modulation of cellular functions in various research applications. -
Ligand for E3 Ligase
CRBN ligand-885 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to target protein ligands through a linker to create proteolysis-targeting chimeras (PROTACs), enabling targeted protein degradation. Its application is crucial in the study of protein homeostasis and the modulation of various cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-230 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN in targeted protein degradation applications. This compound can be conjugated to target protein ligands via a linker, thereby enabling the formation of PROTACs (Proteolysis Targeting Chimeras). CRBN ligand-230 is instrumental in research focused on ubiquitination processes and therapeutic strategies for targeted protein modulation. -
Ligand for E3 Ligase
CRBN ligand-559 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), designed to facilitate the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). It is valuable for research applications focused on targeted protein degradation pathways and the exploration of E3 ligase-mediated ubiquitination processes. -
Ligand for E3 Ligase
CRBN ligand-203 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). It serves a critical role in targeted protein degradation studies and is useful for research into therapeutic applications involving the modulation of protein levels within cells. -
Ligand for E3 Ligase
CRBN ligand-355 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands through a linker to create PROTACs (Proteolysis Targeting Chimeras), enabling targeted protein degradation. It serves as a valuable tool for researchers investigating protein dynamics, ubiquitination pathways, and therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-335 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the construction of PROTACs by linking it to other target protein ligands via a suitable linker. Its application supports the study of targeted protein degradation and the modulation of protein levels in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-561 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein. This compound can be utilized to assemble a PROTAC (Proteolysis Targeting Chimera) by linking it to a target protein ligand through a suitable linker. Research applications include targeted protein degradation and investigations into proteostasis mechanisms, offering insights into therapeutic strategies for various diseases. -
Ligand for E3 Ligase
CRBN ligand-411 is a small molecule ligand that targets the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to specific protein substrates. This compound can be utilized in the development of proteolysis targeting chimeras (PROTACs) by linking to a target protein ligand through a suitable linker. CRBN ligand-411 supports research in targeted protein degradation, enabling the investigation of cellular processes and therapeutic applications in various diseases. -
Ligand for E3 Ligase
CRBN ligand-699 is a small molecule ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, enabling targeted degradation of specific proteins when linked to a target protein ligand through a suitable linker. This compound is instrumental in the development of PROTACs (proteolysis-targeting chimeras) for research applications focused on ubiquitin-mediated protein turnover and targeted therapy strategies. -
Ligand for E3 Ligase
CRBN ligand-755 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), functioning to selectively recruit the CRBN protein. This compound is designed for use in PROTAC (protasome-targeting chimeras) development, allowing for targeted protein degradation in cellular studies. Its ability to link to a target protein ligand via a linker opens avenues for manipulating protein levels in various biological research applications.
