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CRBN ligand-481

Ligand for E3 Ligase

CRBN ligand-481 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits CRBN, facilitating the degradation of target proteins through the mechanism of proteolysis-targeting chimeras (PROTACs). Its application in research includes the development of novel therapeutic strategies targeting specific proteins for degradation, making it a valuable tool for studies in protein regulation and cellular homeostasis.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925098-56-0
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₂BrN₃O₂
Molecular Weight	322.16
SMILES	O=C1NC(=O)CCN1C2=CC(Br)=CC=3C=CN(C32)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.