Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linker
Cis-3-(Aminomethyl)cyclobutanol hydrochloride serves as a PROTAC linker, facilitating the development of protein-targeting chimeras. This compound enables the conjugation of target proteins with E3 ligases, promoting targeted protein degradation pathways. Its application in the synthesis of PROTACs contributes to advances in drug discovery and the study of protein function regulation. -
PROTAC Linker
DBCO-PEG5-GGG-NH2 is a versatile PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound efficiently connects target proteins with E3 ligases, enabling the modulation of protein degradation pathways. Its application in synthetic biology allows researchers to explore targeted protein degradation strategies for therapeutic interventions. -
PROTAC Linker
Boc-CH2-O-(CH2)4-OTs functions as a PROTAC linker, facilitating the design and synthesis of targeted protein degraders. This compound is essential for creating PROTAC AR Degrader-5, contributing to the strategy of regulation of protein levels in cellular systems. Its unique structure enables effective conjugation to ligands, enhancing selectivity and efficacy in targeted degradation applications. This reagent is instrumental for research focused on protein modulation and potential therapeutic interventions in diseases involving protein dysregulation. -
PROTAC Linker
Ethyl 3-(N-BOC-piperidin-4-yl)propioate serves as a PROTAC linker, facilitating the generation of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by connecting E3 ligases and substrates, thus enabling precise modulation of cellular pathways. It is valuable in researchers' efforts to develop novel therapeutics and study protein turnover mechanisms. -
PROTAC Linker
Tetracosanedioic acid is a PROTAC (Proteolysis Targeting Chimeras) linker that facilitates the synthesis of PROTACs for targeted protein degradation. Its structure allows for enhanced solubility and bioconjugation, making it a valuable component in the development of novel therapeutic agents. This compound is instrumental in advancing research in targeted therapeutics and elucidating cellular pathways through protein regulation. -
PROTAC Linker
trans-3-(Aminomethyl)cyclobutanol hydrochloride is a chemical compound utilized as a linker in the development of Proteolysis Targeting Chimeras (PROTACs). This reagent is critical for facilitating the targeted degradation of specific proteins, thus enabling detailed studies on protein function and regulation. Its application in PROTAC synthesis underscores its importance in advancing therapeutic strategies and enhancing drug discovery research. -
PROTAC Linker
3-(4-Boronophenyl)propanoic acid serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is crucial for enhancing the specificity and efficacy of PROTAC-mediated degradation of target proteins. Its incorporation in research applications contributes to the advancement of targeted protein degradation strategies within cellular and molecular biology studies. -
PROTAC Linker
Hydroxy-PEG4-NH-CO-OBn is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This linker facilitates targeted protein degradation by connecting a ligand for the target protein with an E3 ubiquitin ligase. Its chemical stability and hydrophilicity make it particularly suited for enhancing solubility and bioavailability in research applications focused on protein modulation and degradation pathways. -
PROTAC Linker
Docosane-1,22-diol is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the selective degradation of target proteins, enhancing the efficacy of targeted therapies. Its unique structure enables efficient conjugation to both warheads and E3 ligases, making it a valuable tool in drug discovery and development. -
PROTAC linker
Ethyne-C2-Pip-CO-Pip-Boc is a versatile PROTAC linker designed to facilitate targeted protein degradation. This compound plays a crucial role in the synthesis of novel PROTACs, such as QA-68, enabling the selective modulation of protein function. Its unique structure allows for efficient conjugation to target proteins, making it an essential tool for researchers investigating protein interactions and degradation pathways. -
PROTAC Linker
Boc-PEG2-but-1-yne is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligands to target proteins, enabling targeted degradation through the ubiquitin-proteasome system. Its unique structure enhances solubility and provides a versatile option for research applications aimed at studying protein regulation and signaling pathways. -
PROTAC Linker
17-Bromoheptadecanoic acid serves as a versatile PROTAC linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound is pivotal in enhancing the efficacy of targeted protein degradation by facilitating the connection between a protein of interest and an E3 ligase. Its unique structural features enable efficient cellular uptake and conjugation, making it a valuable tool for researchers investigating targeted protein modulation and therapeutic interventions in various diseases. -
PROTAC Linker
PEG3-bis(carbonochloridic acid) is a versatile linker designed for the synthesis of PROTACs (Proteolysis Targeting Chimeras). It facilitates the efficient assembly of bifunctional molecules that can simultaneously bind a target protein and an E3 ligase, promoting the ubiquitin-proteasome mediated degradation of specific proteins. This compound is instrumental in molecular biology research aimed at exploring targeted protein degradation pathways and developing therapeutic agents. -
PROTAC Linkers
Mal-PEG4-Glu(TFP ester)-NH-m-PEG24 is a PEG-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the conjugation of target proteins to E3 ligases, promoting targeted protein degradation. Its application is crucial in the development of therapeutics aimed at modulating protein levels and function in various biological pathways. -
PROTAC Linker
Tert-butyl(hex-5-yn-1-yloxy)dimethylsilane serves as an effective PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). Its structure enables the efficient conjugation of target proteins and E3 ligases, thereby promoting targeted protein degradation. This compound is valuable in the design of novel therapeutic agents for drug discovery and development in various biological studies. -
PROTAC Linker
Diethyl heptanedioate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins through the ubiquitin-proteasome system. It is essential for researchers aiming to explore targeted protein degradation mechanisms and develop novel therapeutic strategies in various disease contexts. -
PROTAC Linker
Tert-butyl 4-(hydroxymethyl)-[1,4'-bipiperidine]-1'-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in creating conjugates that promote the degradation of specific proteins, thereby enabling targeted protein modulation. Its applications in chemical biology and therapeutic research highlight its significance in advancing PROTAC technology and enhancing drug discovery. -
PROTAC Linkers
Br-C4-NHBoc is a PROTAC linker that plays a crucial role in the development of targeted protein degradation strategies. This compound facilitates the construction of bifunctional molecules by linking ligands to E3 ligases, enabling selective degradation of target proteins. It is primarily used in research applications focused on enhancing the efficacy of protein degradation therapies in various disease models. -
PROTAC Linker
Ethyl 3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanoate serves as an effective PROTAC linker essential in the synthesis of PROTAC molecules. By facilitating targeted protein degradation, this compound enhances the selective modulation of protein interactions. Its application is crucial in various biochemical studies aiming to investigate protein functionality and therapeutic interventions. -
PROTAC Linker
Methyl N-(3-methoxy-3-oxopropyl)-N-methyl-beta-alaninate is a PROTAC linker that facilitates the formation of proteolysis-targeting chimeras (PROTACs). This compound is designed to enhance the efficacy of targeted protein degradation by linking an E3 ligase ligand and a target protein ligand. It is suitable for research applications aimed at investigating cellular pathways and therapeutic interventions through modulation of protein levels. -
PROTAC Linker
Tert-butyl 3-(((methylsulfonyl)oxy)methyl)azetidine-1-carboxylate functions as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in research focused on targeted protein degradation, enabling the development of novel therapeutic strategies for various diseases. Its unique chemical properties enhance the efficacy of PROTACs by optimizing ligand-target interactions. -
PROTAC Linker
3-(4-Carboxyphenyl)propanoic acid serves as an effective PROTAC linker used in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ligases for targeted protein degradation, enabling research in cellular signaling pathways and therapeutic interventions. It is essential for creating conjugates that allow for precise manipulation of protein levels within various biological systems. -
PROTAC Linker
21-Bromohenicosanoic acid serves as a versatile PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). Its unique structure allows for efficient conjugation to target proteins, enhancing cellular degradation pathways. This compound is instrumental in research applications focused on targeted protein degradation, chemical biology, and drug discovery. -
PROTAC Linker
5-Oxopentanoic acid is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). It facilitates the covalent attachment of ligands to E3 ligases, enabling targeted protein degradation. This compound is essential for research applications focused on ubiquitin-proteasome system modulation and development of novel therapeutic strategies. -
PROTAC Linker
Methyl 13-bromotridecanoate functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimera (PROTAC) compounds. This reagent is crucial in the synthesis of bifunctional molecules that direct target protein degradation through the ubiquitin-proteasome system. Its application is particularly valuable in chemical biology and drug discovery research. -
PROTAC Linker
Piperazin-1-yl(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanone functions as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound is integral in the design of bifunctional molecules that promote targeted degradation of specific proteins, thereby advancing various research applications in drug discovery and cellular biology. Its unique structure aids in optimizing the efficacy and selectivity of PROTACs in therapeutic contexts. -
PROTAC Linker
(4-(1H-1,2,3-Triazol-4-yl)phenyl)methanol serves as a PROTAC linker, facilitating the development of targeted protein degradation strategies. This compound plays a vital role in synthesizing advanced PROTAC molecules, including Setidegrasib. Its structural properties enhance the formation of bifunctional constructs that enable the selective degradation of specific proteins, aiding research in cancer biology and therapeutic discovery. -
PROTAC Linker
tert-Butyl (3S,4R)-3-fluoro-4-(hydroxymethyl)piperidine-1-carboxylate serves as a versatile PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables efficient conjugation to target proteins, contributing to the degradation of specific proteins through the ubiquitin-proteasome pathway. Its application in research is pivotal for studying protein turnover and developing therapies that harness the cellular protein degradation machinery. -
PROTAC Linker
3-Bromomethyl-cyclobutanecarboxylic acid methyl ester is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). It serves as a critical component in the design and development of targeted protein degradation strategies, enabling the selective modulation of protein levels in cells. This compound facilitates research into innovative therapeutic approaches for various diseases by improving the efficacy and specificity of PROTACs. -
PROTAC Linker
Ethyl trans-4-(aminomethyl)cyclohexanecarboxylate is a synthetic compound utilized as a PROTAC linker. Its structure is pivotal for the development of PROTACs aimed at targeted protein degradation. This linker facilitates the conjugation of targeting moieties to E3 ligase recruiters, thereby enhancing the specificity and efficacy of protein modulation in various biological research applications. -
PROTAC Linker
Nonane-1,9-dithiol is a versatile PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the efficiency of selective protein degradation by connecting target proteins to E3 ligases, promoting ubiquitination and subsequent proteasomal degradation. It is particularly useful in drug discovery and development applications aimed at degrading specific disease-associated proteins. -
PROTAC Linker
tert-Butyl (piperidin-4-ylmethyl)carbamate hydrochloride functions as a PROTAC linker, facilitating the design of proteolysis-targeting chimeras (PROTACs). This compound enhances the targeting and degradation of specific proteins within cellular environments. Its application is crucial in drug discovery and development, particularly in creating targeted therapies that modulate protein levels by exploiting the ubiquitin-proteasome system. -
PROTAC Linker
2-(Piperidin-4-yl)ethyl acetate hydrochloride is a PROTAC linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). This compound is instrumental in the development of targeted protein degradation strategies, enhancing the efficiency of therapeutic interventions in various diseases. Its chemical structure allows for optimized interactions with E3 ligases, making it a valuable tool in chemical biology and drug discovery research. -
PROTAC Linker
Tert-butyl 3-oxo-4-(piperidin-4-yl)piperazine-1-carboxylate serves as an effective PROTAC linker, facilitating the development of targeted protein degradation technologies. This compound is essential for the construction of PROTAC molecules, enabling selective modulation of protein levels in cellular systems. Its unique chemical structure supports enhanced engagement with target proteins, advancing research in targeted therapeutics and chemical biology. -
PROTAC Linker
tert-Butyl 2-(2-iodoethoxy)acetate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound plays a crucial role in chemical biology research, enabling selective degradation of specific target proteins. Its unique structural features make it suitable for various applications in drug discovery and therapeutic development related to targeted protein degradation. -
PROTAC Linker
6-((Tert-Butyldimethylsilyl)oxy)hexan-1-ol is a versatile PROTAC linker employed in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target proteins to an E3 ligase, enabling selective degradation pathways in cellular systems. Its application is critical in drug development research, particularly in the modulation of protein homeostasis and therapeutic targeting of various diseases. -
PROTAC Linker
tert-Butyl 7-(aminomethyl)-2-azaspiro[4.4]nonane-2-carboxylate serves as a versatile PROTAC linker, facilitating the development of targeted protein degradation systems. Its structural features enable effective conjugation within dual-component PROTACs, allowing for enhanced specificity in targeting pathogenic proteins. This compound is crucial for researchers focused on advancing therapeutic strategies in targeted protein degradation and the treatment of various diseases. -
PROTAC Linker
tert-Butyl (6-(2-chloroacetamido)hexyl)carbamate is a specialized PROTAC linker designed for the synthesis of targeted protein degradation agents. Its unique structure facilitates the conjugation of ligands to E3 ligases, enabling efficient degradation of specific target proteins. This compound is essential for researchers developing novel therapies that leverage the ubiquitin-proteasome system for selective protein modulation. -
PROTAC Linker
Ethyl 2-(2-iodoethoxy)acetate serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This compound enhances the selective degradation of target proteins by promoting the formation of a ternary complex with an E3 ligase. Its applications are pivotal in drug discovery and development, particularly for studying protein degradation pathways in various biological contexts. -
PROTAC Linker
2-(6-Bromohexyloxy)tetrahydro-2H-pyran is a key linker for PROTAC (Proteolysis Targeting Chimeras) technology. This compound facilitates the generation of bifunctional degraders, enabling targeted protein degradation by connecting a E3 ligase ligand to a target protein ligand. Its use in PROTAC synthesis supports research applications in cancer therapeutics and cellular pathway modulation, offering insights into protein function and regulation. -
PROTAC Linker
Biotin-PEG3-OH is a polyethylene glycol (PEG) linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the creation of bifunctional molecules that promote the degradation of specific proteins within cells, allowing for targeted protein modulation in biological research. Its unique properties enhance solubility and enable efficient conjugation to protein-binding ligands, making it a valuable tool in the study of targeted protein degradation mechanisms and therapeutic development. -
PROTAC Linker
Potassium succinate trihydrate serves as a versatile PROTAC linker, facilitating the design and synthesis of protein-targeting chimeras. Its unique structure enables effective conjugation between target proteins and E3 ligases, crucial for the targeted degradation of proteins within cellular pathways. This reagent is essential in research applications focusing on drug discovery and the development of novel therapeutic strategies involving targeted protein degradation. -
PROTAC Linker
m-PEG5-Hydrazide is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of protein ligands to E3 ligases, enhancing the targeted degradation of specific proteins within the cell. m-PEG5-Hydrazide is essential for researchers aiming to develop novel therapeutic strategies through targeted protein modulation and degradation. -
PROTAC Linker
4-((4-Iodobenzyl)oxy)piperidine hydrochloride serves as a PROTAC linker, facilitating the synthesis of proteolysis-targeting chimeras (PROTACs). This chemical compound is critical for the effective assembly of PROTACs designed to induce targeted protein degradation, enhancing research in cancer biology and therapeutic development. Its role promotes efficient recruitment of E3 ligases, making it an essential component for studies focused on protein regulation mechanisms. -
PROTAC Linker
Tert-butyl (3-azaspiro[5.5]undecan-9-yl)carbamate is a PROTAC linker that facilitates the creation of proteolysis-targeting chimeras (PROTACs). This compound is crucial for conjugating ligands to E3 ubiquitin ligases, thereby promoting targeted protein degradation. It is a valuable tool in chemical biology research, enabling investigations into protein function and therapeutic interventions for diseases associated with protein dysregulation. -
PROTAC Linker
Dimethyl trans-1,4-cyclohexanedicarboxylate is a PROTAC linker utilized in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the construction of heterobifunctional molecules that promote targeted protein degradation by linking a target ligand to an E3 ligase ligand. Its role is crucial in advancing research in targeted protein modulation and therapeutic intervention strategies. -
PROTAC Linker
Ethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)butanoate is a specialized PROTAC linker utilized in the design and synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, promoting targeted degradation of specific proteins. Its key biological application lies in advancing research in protein modulation and therapeutic development, particularly in cancer biology and cellular signaling pathways. -
PROTAC Linker
tert-Butyl (2-(2-(aminooxy)ethoxy)ethyl)carbamate is a PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This reagent facilitates the recruitment of E3 ligases to target proteins, thereby promoting their ubiquitination and subsequent degradation. It is valuable in studies related to targeted protein degradation and therapeutic development. -
PROTAC Linker
Methyl 3-iodopropiolate is a PROTAC linker that facilitates the targeted degradation of proteins through the ubiquitin-proteasome system. Its reactive iodopropiolate moiety enables efficient conjugation to protein ligands, supporting the development of novel bifunctional molecules in drug discovery. This compound is essential for advancing research applications focused on targeted protein degradation and therapeutic intervention. -
PROTAC Linker
Cbz-azaspiro[3.3]heptane-OH is a specialized PROTAC linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the recruitment of E3 ubiquitin ligases to target proteins, thereby promoting their degradation via the ubiquitin-proteasome pathway. Its unique structure enhances the efficiency and specificity of PROTACs, making it a valuable tool in drug development and molecular biology research.
