Catalog No.
Product Name
Application
Product Information
Citations
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Ligands for E3 Ligase
Nef ligand-2 is a specific ligand for the Nef protein, functioning primarily as a binder that targets E3 ligases. It plays a crucial role in modulating protein interactions and degradation pathways, offering valuable insights into Nef-related signaling mechanisms. This compound is particularly relevant in research applications focused on HIV pathogenesis and the exploration of therapeutic strategies targeting E3 ligase activity. -
CRBN Degrader
WDR5 Degrader-1 is a cereblon (CRBN)-recruiting compound designed to selectively induce degradation of the WDR5 protein. This degrader effectively targets WDR5 while sparing the CRBN neo-substrate IKZF1, facilitating precise manipulation of WDR5 levels in cellular systems. It is a valuable tool for investigating the biological roles of WDR5 in transcriptional regulation and potential therapeutic strategies in diseases associated with dysregulated WDR5 expression. -
KRAS G12D Molecular Glue Degrader
IPS-06061 is a molecular glue degrader that targets the KRAS G12D mutant through the formation of a ternary complex with CRBN. This compound effectively degrades KRAS G12D with a DC50 value of less than 500 nM, demonstrating significant anti-tumor efficacy. It serves as a valuable tool for research into targeted therapies for cancers driven by KRAS mutations. -
Ligands for E3 Ligase
Benzothiazole-CH2(NH-CO-CH2Cl)-CONH-CH2-Ph is a ligand targeting E3 ubiquitin ligase, an essential component of the ubiquitin-proteasome pathway. This compound is designed for use in research applications involving protein degradation and modulation of cellular processes. It can be conjugated to other ligands via a linker to create more complex structures, such as 22-SLF, facilitating the study of E3 ligase interactions and functions. -
Ligands for E3 Ligase
CRBN ligand-83 is a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology. This compound enhances the recruitment of E3 ligases to specific substrates, enabling efficient ubiquitination and subsequent proteasomal degradation of target proteins. CRBN ligand-83 is a valuable tool in chemical biology research for studying protein function and the development of therapeutics that harness the ubiquitin-proteasome system. -
CRBN Ligand
NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip) is a ligand that targets Cereblon (CRBN), a key component of the E3 ubiquitin ligase complex. This compound facilitates the synthesis of PROTAC BRD4 Degrader-22, enabling targeted degradation of the BRD4 protein. Its applications include research in the field of protein degradation and regulation of gene expression, providing a valuable tool for studying the role of BRD4 in various biological processes. -
Thalidomide Analogue
Tetrafluoro-thalidomide is a fluorinated analogue of thalidomide, targeting E3 ligases to activate ubiquitination of proteins for subsequent proteolysis. This compound shows potential significance in studying protein degradation pathways and the therapeutic implications of inhibiting or enhancing E3 ligase activity. Its unique fluorinated structure allows for further derivatization, facilitating the exploration of novel compounds in chemical biology and drug development applications. -
Ligand for E3 Ligase
CRBN ligand-282 serves as a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of cereblon protein. This compound can be conjugated to target protein ligands through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras) to promote targeted protein degradation. Its utility in drug discovery and development makes it a vital tool for studying protein regulation and degradation pathways. -
Ligand for E3 Ligase
CRBN ligand-486 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a key component in the development of proteolysis-targeting chimeras (PROTACs) by facilitating the recruitment of CRBN to target proteins. This reagent is instrumental in cellular studies aimed at understanding protein degradation pathways and has potential applications in targeted protein modulation for therapeutic purposes. -
Ligand for E3 Ligase
CRBN ligand-611 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It is designed to be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studies focused on targeted protein degradation and E3 ligase-mediated pathways in cellular biology. -
Ligand for E3 Ligase
CRBN ligand-656 is an E3 ubiquitin ligase ligand that specifically recruits the cereblon (CRBN) protein. It serves as a critical component in the development of PROTACs by linking to target protein ligands through a spacer or linker. This functionality enables selective degradation of target proteins, facilitating research in protein regulation and therapeutic interventions in diverse biological systems. -
Ligand for E3 Ligase
CRBN ligand-688 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating its recruitment to target proteins. This compound can be utilized in the design of PROTACs (Proteolysis Targeting Chimeras) by linking it to a target protein ligand via a suitable linker. CRBN ligand-688 is valuable for research applications focused on targeted protein degradation and the exploration of synthetic biology pathways. -
Ligand for E3 Ligase
CRBN ligand-492 is a ligand specifically designed for the E3 ubiquitin ligase cereblon (CRBN). This compound effectively recruits the cereblon protein, facilitating the development of proteolysis-targeting chimeras (PROTACs) when conjugated with a target protein ligand through a linker. CRBN ligand-492 is valuable for researchers exploring targeted protein degradation and the modulation of protein homeostasis in various biological contexts. -
Ligand for E3 Ligase
CRBN ligand-742 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to a target protein ligand using a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-742 is utilized in research focused on targeted protein degradation, offering the potential to develop novel therapeutic strategies through the modulation of protein homeostasis. -
E3 Ubiquitin Ligase Ligand
E3 Ligase Ligand 59 is a selective ligand for E3 ubiquitin ligases, particularly FDU73. This compound facilitates the development of PROTACs (proteolysis targeting chimeras) that harness the ubiquitin-proteasome pathway for targeted protein degradation. Its unique properties make it a valuable tool for studying protein regulation and cellular pathways in chemical biology research. -
Ligand for E3 Ligase
CRBN ligand-252 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound is integral for the development of PROTACs (proteolysis-targeting chimeras), allowing for targeted protein degradation in therapeutic applications. CRBN ligand-252 is a valuable tool for researchers investigating ubiquitin-mediated proteolysis and its implications in various biological processes and disease states. -
Ligand for E3 Ligase
CRBN ligand-268 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (Proteolysis Targeting Chimera). CRBN ligand-268 is valuable for research applications in targeted protein degradation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-409 is a small molecule that targets the E3 ubiquitin ligase cereblon (CRBN). It is designed to facilitate the recruitment of CRBN to specific target proteins, enabling the targeted degradation of those proteins through the PROTAC technology platform. This compound is valuable for researchers investigating protein regulation, degradation pathways, and therapeutic applications in diseases involving dysregulated protein levels. -
Ligand for E3 Ligase
CRBN ligand-546 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), which enables the targeted degradation of specific proteins. It is valuable for research in targeted protein degradation and cellular regulation mechanisms. -
Ligand for E3 Ligase
CRBN ligand-199 is a ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a Proteolysis Targeting Chimera (PROTAC). It is invaluable for studies involving targeted protein degradation and modulation of cellular pathways. -
Ligand for E3 Ligase
CRBN ligand-678 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation for innovative therapeutic strategies. Its ability to connect to target protein ligands through a linker positions CRBN ligand-678 as a valuable tool in chemical biology and drug discovery research. -
Ligand for E3 Ligase
CRBN ligand-496 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be strategically linked to target protein ligands via a linker to create a proteolysis-targeting chimera (PROTAC). Its ability to mediate targeted protein degradation makes it valuable for research applications in drug discovery and functional genomics. -
Ligand for E3 Ligase
CRBN ligand-460 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when conjugated with a target protein ligand via a suitable linker. This compound is a valuable tool for research in protein modulation and therapeutic strategies involving targeted protein degradation. -
Ligand for E3 Ligase
CRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions. -
Ligand for E3 Ligase
CRBN Ligand-312 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design of PROTACs by linking it to other target protein ligands via a suitable linker. Its application in targeted protein degradation studies makes it a valuable tool for investigating cellular pathways and protein regulation. -
Ligand for E3 Ligase
CRBN ligand-594 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis targeting chimera). It is instrumental in research applications focusing on targeted protein degradation and the modulation of cellular pathways mediated by CRBN. -
Ligand for E3 Ligase
CRBN ligand-338 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to specific target proteins. By utilizing a linker, CRBN ligand-338 can be employed to create PROTACs (proteolysis-targeting chimeras), enabling targeted degradation of intracellular proteins. This compound serves as a valuable tool for research applications in protein homeostasis, targeted protein degradation, and drug discovery. -
Ligand for E3 Ligase
CRBN ligand-632 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the cereblon protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-632 serves as a valuable tool for researchers investigating ubiquitin-proteasome pathway mechanisms and developing novel therapeutic strategies in cancer and other diseases. -
Ligand for E3 Ligase
CRBN ligand-724 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to synthesize a PROTAC (Proteolysis Targeting Chimera), enabling the selective degradation of specific proteins in cellular assays. Its utility in drug discovery and cellular biology research highlights its relevance in the development of innovative therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-310 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC, enabling targeted protein degradation. It is valuable for research applications involving ubiquitin-proteasome pathway manipulation and therapeutic development. -
Ligand for E3 Ligase
CRBN ligand-315 is an E3 ubiquitin ligase cereblon (CRBN) ligand that facilitates the recruitment of cereblon protein. This compound can be conjugated to a target protein ligand via a linker to create a PROTAC (Proteolysis Targeting Chimera). Its utility in targeted protein degradation makes it a valuable tool for studying protein function and developing potential therapeutics in the field of cellular biology. -
Ligand for E3 Ligase
CRBN ligand-319 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be connected to a target protein ligand through a suitable linker to create a proteolysis-targeting chimera (PROTAC), enabling selective degradation of specific proteins. It serves as a valuable tool in the study of targeted protein degradation and has potential applications in drug discovery and therapeutic development. -
Thalidomide Analog
Thalidomide-O-amido-C8-NHBoc is a thalidomide analog featuring an amide linkage, an octyl alkyl chain, and a carbamate protecting group. This compound serves as a valuable tool in the exploration of thalidomide's mechanisms of action and its derivatives' biological activity. It is applicable in research related to anti-inflammatory and immunomodulatory effects, aiding in the development of novel therapeutic strategies. -
Ligand for E3 Ligase
CRBN ligand-227 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimera) technology. This compound is instrumental in research applications focused on elucidating protein turnover and modulating cellular pathways linked to disease. -
Ligands for E3 Ligase
E3 ligase Ligand 65 is a specific ligand for E3 ubiquitin ligases, facilitating targeted protein degradation through the ubiquitin-proteasome pathway. It serves as a crucial intermediate in the synthesis of AZ'3137, which is utilized in various research applications, including studies on protein homeostasis and therapeutic development. This compound aids in advancing the understanding of E3 ligase function and its implications in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-679 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits CRBN, facilitating targeted protein degradation through the formation of Proteolysis Targeting Chimeras (PROTACs) when linked to a target protein ligand. This compound is valuable in research applications involving protein regulation and therapeutic strategies aimed at disease modulation through selective proteasomal degradation. -
Ligand for E3 Ligase
CRBN ligand-387 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), enabling the recruitment of the cereblon protein. This compound can be conjugated to a target protein ligand through a linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). It is a valuable tool in research applications focused on targeted protein degradation and E3 ligase-mediated pathways. -
Ligand for E3 Ligase
CRBN ligand-743 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), which facilitates the recruitment of cereblon to target proteins. This compound can be connected to a target protein ligand through a linker, enabling the formation of a proteolysis-targeting chimera (PROTAC). Its key biological activity lies in promoting targeted degradation of specific proteins, making it valuable for research in protein regulation and therapeutic applications. -
Ligand for E3 Ligase
5-Fluoro-pomalidomide is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. This compound effectively recruits the cereblon protein, making it a valuable tool for the design of PROTACs (Proteolysis Targeting Chimeras) when linked to target protein ligands through a suitable linker. Research applications include studies in targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity. -
Ligand for E3 Ligase
CRBN ligand-198 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through the PROTAC (proteolysis-targeting chimeras) approach. This compound is valuable for research applications focused on studying protein degradation pathways and developing novel therapeutics that leverage the ubiquitin-proteasome system. -
Ligand for E3 Ligase
CRBN ligand-725 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN) that facilitates the recruitment of cereblon to target proteins. This compound can be utilized in the construction of proteolysis-targeting chimeras (PROTACs), allowing for the targeted degradation of specific proteins. Its application is crucial in the study of protein homeostasis and the development of novel therapeutic strategies in various diseases. -
Ligand for E3 Ligase
CRBN ligand-527 functions as a ligand for the E3 ubiquitin ligase cereblon (CRBN). It effectively recruits the CRBN protein and can be utilized to create a PROTAC by linking it to a target protein ligand through a suitable linker. This compound is valuable for research applications focused on targeted protein degradation and the study of protein turnover mechanisms. -
Ligand for E3 Ligase
CRBN ligand-577 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein in targeted protein degradation applications. This compound can be conjugated to a target protein ligand through a suitable linker, enabling the formation of a PROTAC (proteolysis-targeting chimera). CRBN ligand-577 supports research in the development of targeted therapies by promoting selective ubiquitination and degradation of specific proteins within the cellular environment. -
Ligand for E3 Ligase
Desamino lenalidomide-ethynyl is an E3 ubiquitin ligase cereblon (CRBN) ligand that effectively recruits the cereblon protein. This compound can be conjugated with a target protein ligand through a linker to generate a PROTAC, facilitating targeted protein degradation for research applications. Its unique mechanism of action enables studies in protein homeostasis and therapeutic interventions in cancer and other diseases. -
Thalidomide Analog
Thalidomide-4-F,5-Br is a Thalidomide analogue designed to enhance E3 ligase recruitment for the ubiquitination and subsequent degradation of target proteins. This compound exhibits potential biological activity in modulating protein turnover, making it a valuable tool in diverse research applications, including cancer studies and the investigation of cellular signaling pathways. Furthermore, the presence of fluorine and bromine allows for further derivatization, enabling the exploration of new molecular properties and activities. -
Ligand for E3 Ligase
CRBN ligand-383 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be conjugated to specific target protein ligands using a linker to generate PROTAC molecules. Its primary applications include targeted protein degradation and investigation of CRBN-mediated pathways in cellular processes. -
Ligand for E3 Ligase
CRBN ligand-205 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. It is designed for use in the development of PROTACs, allowing for targeted degradation of specific proteins through the formation of a linkage between CRBN and a target protein ligand. This compound is essential for research in protein regulation and therapeutic applications in targeted protein degradation strategies. -
Ligand for E3 Ligase
CRBN ligand-731 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this critical protein. This compound can be conjugated to a target protein ligand through a linker, enabling the development of proteolysis-targeting chimeras (PROTACs). CRBN ligand-731 is instrumental in studies focused on targeted protein degradation and offers valuable insights into cellular protein regulation. -
Ligand for E3 Ligase
CRBN ligand-710 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), utilized to facilitate the recruitment of CRBN in targeted protein degradation. It can be conjugated to a specific target protein ligand through a linker, enabling the formation of PROTACs (proteolysis-targeting chimeras). This compound is instrumental in studies focusing on protein regulation and degradation pathways, thereby advancing research in cancer therapeutics and other diseases related to protein homeostasis. -
Ligand for E3 Ligase
CRBN ligand-745 is a specific ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this protein for targeted protein degradation. By connecting CRBN ligand-745 to a target protein ligand through a linker, it serves as an essential component in the design of PROTACs (proteolysis-targeting chimeras). This functionality enables researchers to explore novel therapeutic strategies that manipulate protein levels within cells, advancing the understanding of disease mechanisms and drug development.
