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CRBN ligand-227

Ligand for E3 Ligase

CRBN ligand-227 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the cereblon protein, enabling targeted protein degradation through PROTAC (Proteolysis Targeting Chimera) technology. This compound is instrumental in research applications focused on elucidating protein turnover and modulating cellular pathways linked to disease.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1482078-60-3
Applications	Ligand for E3 Ligase
Formula	C₁₂H₁₂FN₃O₃
Molecular Weight	265.24
SMILES	O=C(NC1C(=O)NC(=O)CC1)C2=CC=C(N)C=C2F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.