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CRBN ligand-83

Ligands for E3 Ligase

CRBN ligand-83 is a ligand for the CRBN E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (proteolysis-targeting chimera) technology. This compound enhances the recruitment of E3 ligases to specific substrates, enabling efficient ubiquitination and subsequent proteasomal degradation of target proteins. CRBN ligand-83 is a valuable tool in chemical biology research for studying protein function and the development of therapeutics that harness the ubiquitin-proteasome system.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	3036607-28-7
Applications	Ligands for E3 Ligase
Formula	C₁₂H₁₁BrFNO₃
Molecular Weight	316.12
SMILES	O=C(C(C1=CC=C(Br)C(OC)=C1F)CC2)NC2=O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.