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CRBN ligand-486

Ligand for E3 Ligase

CRBN ligand-486 is a selective ligand for the E3 ubiquitin ligase cereblon (CRBN). It serves as a key component in the development of proteolysis-targeting chimeras (PROTACs) by facilitating the recruitment of CRBN to target proteins. This reagent is instrumental in cellular studies aimed at understanding protein degradation pathways and has potential applications in targeted protein modulation for therapeutic purposes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925097-39-6
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₄N₄O₂
Molecular Weight	258.28
SMILES	O=C1NC(=O)CCN1C2=CC=C(N)C3=C2C=CN3C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.