CRBN ligand-611

Catalog No.: A81187
Ligand for E3 Ligase
CRBN ligand-611 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It is designed to be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studies focused on targeted protein degradation and E3 ligase-mediated pathways in cellular biology.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
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Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
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Nature volume 574, pages268-272 (2019)
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Nature volume 551, pages639-643 (2017)
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Biological Activity
DescriptionCRBN ligand-611 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of this essential protein. It is designed to be conjugated to target protein ligands through a linker, enabling the formation of proteolysis-targeting chimeras (PROTACs). This compound is valuable for studies focused on targeted protein degradation and E3 ligase-mediated pathways in cellular biology.
Product Information
Catalog NumA81187
FormulaC16H19N5O2
Molecular Weight313.36
CAS Number2766179-60-4
SMILESO=C1NC(=O)CCN1C2=CC=C(C=3NC=CC23)N4CCNCC4
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