Fig. 1 · Structure
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Thalidomide-4-F,5-Br
Thalidomide Analog
Thalidomide-4-F,5-Br is a Thalidomide analogue designed to enhance E3 ligase recruitment for the ubiquitination and subsequent degradation of target proteins. This compound exhibits potential biological activity in modulating protein turnover, making it a valuable tool in diverse research applications, including cancer studies and the investigation of cellular signaling pathways. Furthermore, the presence of fluorine and bromine allows for further derivatization, enabling the exploration of new molecular properties and activities.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2740657-28-5 |
| Applications | Thalidomide Analog |
| Formula | C13H8BrFN2O4 |
| Molecular Weight | 355.12 |
| SMILES | O=C1NC(C(CC1)N2C(C3=CC=C(C(F)=C3C2=O)Br)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.