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CRBN ligand-546

Ligand for E3 Ligase

CRBN ligand-546 is a ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of the CRBN protein. This compound can be conjugated to a target protein ligand through a linker to create a PROTAC (Proteolysis Targeting Chimera), which enables the targeted degradation of specific proteins. It is valuable for research in targeted protein degradation and cellular regulation mechanisms.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2766179-42-2
Applications	Ligand for E3 Ligase
Formula	C₁₇H₂₀N₄O₂
Molecular Weight	312.37
SMILES	O=C1NC(=O)CCN1C=2C=CC=C3C2C=CN3C4CCNCC4

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.