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NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip)

CRBN Ligand

NH2-MeO-Ph-amide-(2,6-Dioxo-3-Pip) is a ligand that targets Cereblon (CRBN), a key component of the E3 ubiquitin ligase complex. This compound facilitates the synthesis of PROTAC BRD4 Degrader-22, enabling targeted degradation of the BRD4 protein. Its applications include research in the field of protein degradation and regulation of gene expression, providing a valuable tool for studying the role of BRD4 in various biological processes.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	1504209-32-8
Applications	CRBN Ligand
Formula	C₁₃H₁₅N₃O₄
Molecular Weight	277.28
SMILES	O=C(NC(CC1)C(NC1=O)=O)C2=CC=C(N)C=C2OC

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.