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Tetrafluoro-thalidomide

Thalidomide Analogue

Tetrafluoro-thalidomide is a fluorinated analogue of thalidomide, targeting E3 ligases to activate ubiquitination of proteins for subsequent proteolysis. This compound shows potential significance in studying protein degradation pathways and the therapeutic implications of inhibiting or enhancing E3 ligase activity. Its unique fluorinated structure allows for further derivatization, facilitating the exploration of novel compounds in chemical biology and drug development applications.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	179033-21-7
Applications	Thalidomide Analogue
Formula	C₁₃H₆F₄N₂O₄
Molecular Weight	330.19
SMILES	O=C1C2=C(C(N1C3C(NC(CC3)=O)=O)=O)C(F)=C(F)C(F)=C2F

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.