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CRBN ligand-460

Ligand for E3 Ligase

CRBN ligand-460 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of CRBN, enabling targeted protein degradation through the formation of PROTACs when conjugated with a target protein ligand via a suitable linker. This compound is a valuable tool for research in protein modulation and therapeutic strategies involving targeted protein degradation.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925072-52-0
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀N₄O₃
Molecular Weight	270.25
SMILES	O=CC1=CC=2C=NN=CC2C(=C1)N3C(=O)NC(=O)CC3

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.