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5-Fluoro-pomalidomide

Ligand for E3 Ligase

5-Fluoro-pomalidomide is an E3 ubiquitin ligase ligand that targets cereblon (CRBN) to facilitate protein degradation. This compound effectively recruits the cereblon protein, making it a valuable tool for the design of PROTACs (Proteolysis Targeting Chimeras) when linked to target protein ligands through a suitable linker. Research applications include studies in targeted protein degradation and the modulation of cellular pathways influenced by CRBN activity.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2713422-01-4
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀FN₃O₄
Molecular Weight	291.24
SMILES	O=C1NC(=O)C(N2C(=O)C=3C=C(F)C=C(N)C3C2=O)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.