CRBN ligand-280

Catalog No.: A81201
Ligand for E3 Ligase
CRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions.
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Adooq Products cited in reputable paper
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Biological Activity
DescriptionCRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions.
Product Information
Catalog NumA81201
FormulaC13H10BrN3O2
Molecular Weight320.15
CAS Number2925073-70-5
SMILESO=C1NC(=O)CCN1C=2C=CC3=CC(Br)=CN=C3C2
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