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CRBN ligand-280

Ligand for E3 Ligase

CRBN ligand-280 is an E3 ubiquitin ligase ligand that specifically targets cereblon (CRBN) to facilitate protein degradation. By recruiting the CRBN protein, this compound can be utilized in the development of PROTACs (proteolysis-targeting chimeras) when linked to a target protein ligand through a suitable linker. Its application in targeted protein degradation research provides a powerful tool for investigating cellular processes and therapeutic interventions.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	2925073-70-5
Applications	Ligand for E3 Ligase
Formula	C₁₃H₁₀BrN₃O₂
Molecular Weight	320.15
SMILES	O=C1NC(=O)CCN1C=2C=CC3=CC(Br)=CN=C3C2

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.