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CRBN ligand-678

Ligand for E3 Ligase

CRBN ligand-678 is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN), facilitating the recruitment of CRBN to target proteins. This compound can be utilized in the design and synthesis of PROTACs (proteolysis-targeting chimeras), enabling targeted protein degradation for innovative therapeutic strategies. Its ability to connect to target protein ligands through a linker positions CRBN ligand-678 as a valuable tool in chemical biology and drug discovery research.

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Specifications

Manufacturer	Adooq Bioscience
Actions	Ligand / Binder
CAS Number	458151-38-7
Applications	Ligand for E3 Ligase
Formula	C₁₇H₁₃N₃O₄
Molecular Weight	323.31
SMILES	O=C1NC(=O)C(N2C(=O)C=3C=CC=C4C=C(N)C=C(C2=O)C43)CC1

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.