Fig. 1 · Structure
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Pyrene-PEG2-azide
PROTAC linker
Pyrene-PEG2-azide is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). It features an azide functional group that enables copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules, as well as strain-promoted azide-alkyne cycloaddition (SPAAC) reactions with DBCO or BCN groups. This reagent is essential for the development of targeted protein degradation strategies and offers versatility in chemical biology applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2135330-58-2 |
| Applications | PROTAC linker |
| Formula | C23H22N4O3 |
| Molecular Weight | 402.45 |
| SMILES | O=C(NCCOCCOCCN=[N+]=[N-])C1=CC=C2C=CC3=CC=CC4=CC=C1C2=C43 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.