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Src

Inhibitory Selectivity
Catalog No.Inhibitor Name SrcLckFynLynYesOther
A10290Dasatinib
****
Abl,c-Kit (D816V),c-Kit (wt)
A10108Saracatinib
***
***
**
***
EGFR (L861Q),c-YES,EGFR (L858R)
A10161Bosutinib
****
Abl
A11177KX2-391
**
A10661NVP-BHG712
*
EphB4,C-Raf,c-Abl
A12723PP2
***
***
***
EGFR
A12724PP1
***
***
**
Kit,EGFR,Bcr-Abl
A15518SU6656
*
*
*
*
A16320Dasatinib Monohydrate
****
Abl ,c-Kit (D816V),c-Kit (wt)
A14117WH-4-023
****
****
A10766Quercetin
Sirtuin,PKC,PI3Kγ
A11288A-770041
*
A12417MLR 1023
**
A132321-NA-PP1
****
****
 c-Abl, CDK2, CAMK II
A13415MCB-613
***
****
****
A13819TG 100801
****
****
VEGFR1, VEGFR2, FGFR1
A13820TG 100572
****
****
VEGFR1, VEGFR2, FGFR1
A13868PD 166285
 FGFR1, PDGFRβ, Wee1
A16241AZM475271
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.



38 Item(s)

per page

Set Descending Direction
Catalog No. Product Name Application Product Information
A14117 SALE

WH 4-023

dual Lck/Src inhibitor
WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively.
A12214 SALE

KX1-004

Src-PTK inhibitor
KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL.
A13868

PD-166285

Src inhibitor
PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1).
A15060

Dasatinib hydrochloride

Src inhibitor
Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of ??1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM.
A15260

TG 100572 HCl

VEGFR2/Src kinase inhibitor
TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively.
A15518 SALE

SU6656

SRC inhibitor
SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively).
A11471

KX2-391 2HCl

Src inhibitor
KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines.
A13415

MCB-613

SRC stimulator
MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator.
A11288

A-770041

Lck inhibitor
A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling.
A14323

A419259

Src inhibitor
A419259 trihydrochloride is an apoptosis inducing agent that inhibits Src family kinases (c-Src).
A10161 SALE

Bosutinib (SKI-606)

Src inhibitor
Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.
A16240

MNS

Src/Syk inhibitor
MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases.
A16241

AZM475271

Src inhibitor
AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2.
A16244

T338C Src-IN-2

Src inhibitor
T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM.
A16243

T338C Src-IN-1

Src inhibitor
T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase).
A15140

Lck Inhibitor

Lck Inhibitor
Lck Inhibitor is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM.
A15141

Lck inhibitor 2

Lck inhibitor
Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively .
A16242

CPDA

SHIP2 inhibitor
CPDA is a novel potent SHIP2 inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes.
A16086

Tilfrinib

Brk inhibitor
Tilfrinib is a potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 3.15 nM).
A12234

Scutellarein

-
Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases.
A10108 SALE

Saracatinib (AZD0530)

Src/Abl inhibitor
Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively.
A10290 SALE

Dasatinib (BMS-354825)

Abl-Src inhibitor
Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2.
A10661 SALE

NVP-BHG712

EphB4 inhibitor
NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3.
A10766 SALE

Quercetin (Sophoretin)

MAO-B inhibitor
Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C.
A11177 SALE

KX2-391

Src inhibitor

KX2-391 is a novel non-ATP competitive substrate-pocket directed SRC inhibitor.
A11207 SALE

PP121

PI3K Inhibitor
PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR).
A12417 SALE

MLR 1023

-
MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM)
A12724 SALE

PP1

Src Inhibitor
PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
A12723 SALE

PP2

Src Inhibitor
PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM).
A13069 SALE

XL-228

IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases.
A13232 SALE

1-NA-PP1

Src Kinase inhibitor
1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl
A13167 SALE

AMG-47a

Lck inhibitor
AMG-47a is an orally bioavailable potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED50 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice.
A13573 SALE

PP1 Analog II, 1NM-PP1

-
PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors.
A13821

CGP77675

Src inhibitor
CGP77675 is a potent Src kinase inhibitor. CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively).
A13820

TG 100572

VEGFR2/Src inhibitor
TG 100572 is VEGFR2 and Src kinase inhibitor.
A13819

TG 100801

VEGFR2/Src inhibitor
TG 100801 is a VEGFR2 targeting prodrug currently in a clinical trial. The active form is TG100572.
A13290

A-419259

SFK inhibitor
A-419259 is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM).
A16265

Lyn-IN-1

dual Bcr-Abl/Lyn inhibitor
Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1.

38 Item(s)

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Target
  1. Abl (2)
  2. Aurora A (1)
  3. Bcr-Abl (1)
  4. C-Raf (Raf-1) (1)
  5. EphB4 (1)
  6. FGFR1 (1)
  7. FGFR2 (1)
  8. FGFR3 (1)
  9. IGF1R (1)
  10. Src (2)
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  1. Activator (1)
  2. Inhibitor (34)
  3. Stimulator (1)

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