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| Catalog No. | Inhibitor Name | Src | Lck | Fyn | Lyn | Yes | Other |
|---|---|---|---|---|---|---|---|
| A10290 | Dasatinib | **** | Abl,c-Kit (D816V),c-Kit (wt) | ||||
| A10108 | Saracatinib | *** | *** | ** | *** | EGFR (L861Q),c-YES,EGFR (L858R) | |
| A10161 | Bosutinib | **** | Abl | ||||
| A11177 | KX2-391 | ** | |||||
| A10661 | NVP-BHG712 | * | EphB4,C-Raf,c-Abl | ||||
| A12723 | PP2 | *** | *** | *** | EGFR | ||
| A12724 | PP1 | *** | *** | ** | Kit,EGFR,Bcr-Abl | ||
| A15518 | SU6656 | * | * | * | * | ||
| A16320 | Dasatinib Monohydrate | **** | Abl ,c-Kit (D816V),c-Kit (wt) | ||||
| A14117 | WH-4-023 | **** | **** | ||||
| A10766 | Quercetin | Sirtuin,PKC,PI3Kγ | |||||
| A11288 | A-770041 | * | |||||
| A12417 | MLR 1023 | ** | |||||
| A13232 | 1-NA-PP1 | **** | **** | c-Abl, CDK2, CAMK II | |||
| A13415 | MCB-613 | *** | **** | **** | |||
| A13819 | TG 100801 | **** | **** | VEGFR1, VEGFR2, FGFR1 | |||
| A13820 | TG 100572 | **** | **** | VEGFR1, VEGFR2, FGFR1 | |||
| A13868 | PD 166285 | FGFR1, PDGFRβ, Wee1 | |||||
| A16241 | AZM475271 | **** |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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7-Hydroxy-4H-chromen-4-one
Catalog No. A22365 Src kinase inhibitor7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM. Learn More -
T338C Src-IN-1
Catalog No. A16243 Src inhibitorT338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase). Learn More -
AZM475271
Catalog No. A16241 Src inhibitorAZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2. Learn More -
MNS
Catalog No. A16240 Src/Syk inhibitorMNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. Learn More -
A-770041
Catalog No. A11288 Lck inhibitorA-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. Learn More -
MCB-613
Catalog No. A13415 SRC stimulatorMCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator. Learn More -
KX2-391 2HCl
Catalog No. A11471 Src inhibitorKX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Learn More -
SU6656
Catalog No. A15518 SRC inhibitorSU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). Learn More -
TG 100572 HCl
Catalog No. A15260 VEGFR2/Src kinase inhibitorTG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More -
T338C Src-IN-2
Catalog No. A16244 Src inhibitorT338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM. Learn More -
DGY-06-116
Catalog No. A22077 Src inhibitorDGY-06-116 is an irreversible covalent, selective Src inhibitor. Learn More -
UM-164
Catalog No. A19895 c-Src inhibitorUM-164 (DAS-DFGO-II) is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β. Learn More -
WEHI-345 analog
Catalog No. A20322 Src inhibitorWEHI-345 analog is a Src inhibitor, extracted from patent WO/2012003544A1, compound example 71. Learn More -
TL02-59
Catalog No. A20302 Src-family kinase Fgr inhibitorTL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. Learn More -
KB SRC 4
Catalog No. A20111 c-Src inhibitorKB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity. Learn More -
CSF1R-IN-2
Catalog No. A20013 SRC inhibitorCSF1R-IN-2 (compound 5) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively. Learn More -
1-Naphthyl PP1 hydrochloride
Catalog No. A21790 Src/c-Abl inhibitor1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Learn More -
Tirbanibulin Mesylate
Catalog No. A21620 Src inhibitorTirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Learn More -
Src Inhibitor 1
Catalog No. A12299 Src tyrosine kinase inhibitorSrc Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Learn More -
eCF506
Catalog No. A13126 Src inhibitoreCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase Src with an IC50 of less than 0.5 nM. Learn More -
Dasatinib hydrochloride
Catalog No. A15060 Src inhibitorDasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. Learn More -
PD-166285
Catalog No. A13868 Src inhibitorPD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1). Learn More -
A419259
Catalog No. A14323 Src inhibitorA419259 is an apoptosis inducing agent that inhibits Src family kinases (c-Src). Learn More -
NVP-BHG712
Catalog No. A10661 EphB4 inhibitorNVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Learn More -
Dasatinib (BMS-354825)
Catalog No. A10290 Abl-Src inhibitorDasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2. Learn More -
KX1-004
Catalog No. A12214 Src-PTK inhibitorKX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. Learn More -
WH 4-023
Catalog No. A14117 dual Lck/Src inhibitorWH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively. Learn More -
Bosutinib (SKI-606)
Catalog No. A10161 Src inhibitorBosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer. Learn More -
Saracatinib (AZD0530)
Catalog No. A10108 Src/Abl inhibitorSaracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More -
AZD0424
Catalog No. A19488 Src/Abl kinase inhibitorAZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells. Learn More -
PP2
Catalog No. A12723 Src InhibitorPP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM). Learn More -
PP1
Catalog No. A12724 Src InhibitorPP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl Learn More -
MLR 1023
Catalog No. A12417 MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM) Learn More -
KX2-391
Catalog No. A11177 Src inhibitorKX2-391 is a novel non-ATP competitive substrate-pocket directed SRC inhibitor.
Learn More -
PP121
Catalog No. A11207 PI3K InhibitorPP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More -
Quercetin (Sophoretin)
Catalog No. A10766 MAO-B inhibitorQuercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More -
XL-228
Catalog No. A13069 IGF-1R, Aurora, FGFR, ABL, SRC inhibitorXL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More -
Lyn-IN-1
Catalog No. A16265 dual Bcr-Abl/Lyn inhibitorLyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1. Learn More -
1-NA-PP1
Catalog No. A13232 Src Kinase inhibitor1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl Learn More -
TC-S 7003 (Lck Inhibitor)
Catalog No. A15140 Lck InhibitorTC-S 7003 is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. Learn More -
Lck inhibitor 2
Catalog No. A15141 Lck inhibitorLck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively . Learn More -
A-419259
Catalog No. A13290 SFK inhibitorA-419259 trihydrochloride is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM). Learn More -
TG 100801
Catalog No. A13819 VEGFR2/Src inhibitorTG 100801 is a VEGFR2 targeting prodrug currently in a clinical trial. The active form is TG100572. Learn More -
TG 100572
Catalog No. A13820 -
Scutellarein
Catalog No. A12234 Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More -
Tilfrinib
Catalog No. A16086 Brk inhibitorTilfrinib is a potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 3.15 nM). Learn More -
CGP77675
Catalog No. A13821 Src inhibitorCGP77675 is a potent Src kinase inhibitor. CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). Learn More -
PP1 Analog II, 1NM-PP1
Catalog No. A13573 PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Learn More -
CPDA
Catalog No. A16242 SHIP2 inhibitorCPDA is a novel potent SHIP2 inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes. Learn More -
AMG-47a
Catalog No. A13167 Lck inhibitorAMG-47a is an orally bioavailable potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED50 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. Learn More
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