Src

Catalog No.Inhibitor Name SrcLckFynLynYesOther
A10290Dasatinib
****
Abl,c-Kit (D816V),c-Kit (wt)
A10108Saracatinib
***
***
**
***
EGFR (L861Q),c-YES,EGFR (L858R)
A10161Bosutinib
****
Abl
A11177KX2-391
**
A10661NVP-BHG712
*
EphB4,C-Raf,c-Abl
A12723PP2
***
***
***
EGFR
A12724PP1
***
***
**
Kit,EGFR,Bcr-Abl
A15518SU6656
*
*
*
*
A16320Dasatinib Monohydrate
****
Abl ,c-Kit (D816V),c-Kit (wt)
A14117WH-4-023
****
****
A10766Quercetin
Sirtuin,PKC,PI3Kγ
A11288A-770041
*
A12417MLR 1023
**
A132321-NA-PP1
****
****
c-Abl, CDK2, CAMK II
A13415MCB-613
***
****
****
A13819TG 100801
****
****
VEGFR1, VEGFR2, FGFR1
A13820TG 100572
****
****
VEGFR1, VEGFR2, FGFR1
A13868PD 166285
FGFR1, PDGFRβ, Wee1
A16241AZM475271
****

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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  1. 7-Hydroxy-4H-chromen-4-one

    Catalog No. A22365
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    Src kinase inhibitor
    7-Hydroxychromone is a Src kinase inhibitor with an IC50 of <300 μM. Learn More
  2. T338C Src-IN-1

    Catalog No. A16243
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    Src inhibitor
    T338C Src-IN-1 is a potent mutant-Src T338C inhibitor; exhibited the most potent inhibition of T338C(IC50=111 nM) relative to WT c-Src (10-fold increase). Learn More
  3. AZM475271

    Catalog No. A16241
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    Src inhibitor
    AZM475271 is a potent and selective Src kinase inhibitor with IC50 of 5 nM; no inhibitory activity on Flt3, KDR, Tie-2. Learn More
  4. MNS

    Catalog No. A16240
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    Src/Syk inhibitor
    MNS is a potent and selective inhibitor of Src and Syk tyrosine kinases. Learn More
  5. A-770041

    Catalog No. A11288
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    Lck inhibitor
    A-770041 is selective and orally active Src-family Lck inhibitor; A-770041 is a 147 nM inhibitor of Lck (1 mM ATP) and is 300-fold selective against Fyn, the other Src family kinase involved in T-cell signaling. Learn More
  6. MCB-613

    Catalog No. A13415
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    SRC stimulator
    MCB-613 is a potent, pan steroid receptor coactivator (SRC) stimulator. Learn More
  7. KX2-391 2HCl

    Catalog No. A11471
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    Src inhibitor
    KX2-391 2Hcl is the first clinical Src inhibitor (peptidomimetic class) that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Learn More
  8. SU6656

    Catalog No. A15518
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    SRC inhibitor
    SU6656 is a selective inhibitor of Src kinases, Including Src, Yes, Lyn, and Fyn (IC50 = 280, 20, 130, 170 nM, respectively). Learn More
  9. TG 100572 HCl

    Catalog No. A15260
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    VEGFR2/Src kinase inhibitor
    TG 100572 is a multi-targeted kinase inhibitor that inhibit select growth factor receptor tyrosine kinases and Src familt kinases with IC50 values of 2/7/2/1/0.5 nM for VEGFR1/VEGFR2/FGFR1/Src/Fyn kianse respectively. Learn More
  10. T338C Src-IN-2

    Catalog No. A16244
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    Src inhibitor
    T338C Src-IN-2 is a potent mutant c-Src T338C kinase inhibitor with IC50 of 317 nM; also inhibits T338C/V323A and T338C/V323S with IC50 of 57 nM/19 nM. Learn More
  11. DGY-06-116

    Catalog No. A22077
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    Src inhibitor
    DGY-06-116 is an irreversible covalent, selective Src inhibitor. Learn More
  12. UM-164

    Catalog No. A19895
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    c-Src inhibitor
    UM-164 (DAS-DFGO-II) is a highly potent inhibitor of c-Src with a Kd of 2.7 nM. UM-164 also potently inhibits p38α and p38β. Learn More
  13. WEHI-345 analog

    Catalog No. A20322
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    Src inhibitor
    WEHI-345 analog is a Src inhibitor, extracted from patent WO/2012003544A1, compound example 71. Learn More
  14. TL02-59

    Catalog No. A20302
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    Src-family kinase Fgr inhibitor
    TL02-59 is an orally active, selective Src-family kinase Fgr inhibitor with an IC50 of 0.03 nM. Learn More
  15. KB SRC 4

    Catalog No. A20111
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    c-Src inhibitor
    KB SRC 4 is a potent, and highly selective c-Src inhibitor, with a Ki of 44 nM and a Kd of 86 nM, and shows no inhibition on c-Abl up to 125 μM; KB SRC 4 has antitumor activity. Learn More
  16. CSF1R-IN-2

    Catalog No. A20013
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    SRC inhibitor
    CSF1R-IN-2 (compound 5) is an oral-active inhibitor of SRC, MET and c-FMS, with IC50 values of 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively. Learn More
  17. 1-Naphthyl PP1 hydrochloride

    Catalog No. A21790
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    Src/c-Abl inhibitor
    1-Naphthyl PP1 hydrochloride is a selective inhibitor of src family kinases v-Src and c-Fyn as well as the tyrosine kinase c-Abl (IC50 values are 1.0, 0.6, 0.6, 18 and 22 μM for v-Src, c-Fyn, c-Abl, CDK2 and CAMK II respectively). Learn More
  18. Tirbanibulin Mesylate

    Catalog No. A21620
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    Src inhibitor
    Tirbanibulin Mesylate (KX2-391 Mesylate) is an inhibitor of Src that targets the peptide substrate site of Src, with GI50 of 9-60 nM in cancer cell lines. Learn More
  19. Src Inhibitor 1

    Catalog No. A12299
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    Src tyrosine kinase inhibitor
    Src Inhibitor 1 is a potent and selective dual site Src tyrosine kinase inhibitor with IC50 values of 44 nM for Src and 88nM for Lck. Learn More
  20. eCF506

    Catalog No. A13126
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    Src inhibitor
    eCF506 is a highly potent and orally bioavailable inhibitor of the non-receptor tyrosine kinase Src with an IC50 of less than 0.5 nM. Learn More
  21. Dasatinib hydrochloride

    Catalog No. A15060
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    Src inhibitor
    Dasatinib hydrochloride is a potent and dual Abl/ Src inhibitor IC50 of <1 nM/0.8 nM respectively; also inhibit c-Kit (WT)/c-Kit (D816V) with IC50 of 79 nM/37 nM. Learn More
  22. PD-166285

    Catalog No. A13868
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    Src inhibitor
    PD 166285 is a potent inhibitor of the tyrosine kinases c-Src, Flg (fibroblast growth factor receptor 1, FGFR1). Learn More
  23. A419259

    Catalog No. A14323
    Src inhibitor
    A419259 is an apoptosis inducing agent that inhibits Src family kinases (c-Src). Learn More
  24. NVP-BHG712

    Catalog No. A10661
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    EphB4 inhibitor
    NVP-BHG712 is a selective inhibitor of EphB4 kinase that exhibits selectivity for EphB4 over more than 40 other kinases in vitro, including FGFR3. Learn More
  25. Dasatinib (BMS-354825)

    Catalog No. A10290
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    Abl-Src inhibitor
    Dasatinib (BMS-354825) is an oral multi- BCR/ABL and Src family tyrosine kinase inhibitor. The main targets of dasatinib, are BCR/ABL, Src, c-Kit, ephrin receptors, and several other tyrosine kinases, but not erbB kinases such as EGFR or Her2. Learn More
  26. KX1-004

    Catalog No. A12214
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    Src-PTK inhibitor
    KX1-004 is a potent small molecule inhibitor of Src-PTK as a potential protective drug for NIHL. Learn More
  27. WH 4-023

    Catalog No. A14117
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    dual Lck/Src inhibitor
    WH-4-023 is a potent and selective dual Lck/Src inhibitor with IC50 of 2 nM/6 nM for Lck and Src kinase respectively. Learn More
  28. Bosutinib (SKI-606)

    Catalog No. A10161
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    Src inhibitor
    Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer. Learn More
  29. Saracatinib (AZD0530)

    Catalog No. A10108
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    Src/Abl inhibitor
    Saracatinib (AZD0530) is a highly selective, orally available, dual-specific Src/Abl kinase inhibitor with IC50 of 2.7 and 30 nM for c-Src and Abl kinase, respectively. Learn More
  30. AZD0424

    Catalog No. A19488
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    Src/Abl kinase inhibitor
    AZD0424 is an orally active, and dual selective Src/Abl kinase inhibitor with potential antineoplastic activity. AZD0424 induces apoptosis and cell cycle arrest in lymphoma cells. Learn More
  31. PP2

    Catalog No. A12723
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    Src Inhibitor
    PP2 is a selective inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 4 and 5 nM respectively). Displays > 10000-fold selectivity over ZAP-70 and JAK2. Moderately inhibits CSK (IC50 = 0.73 μM). Learn More
  32. PP1

    Catalog No. A12724
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    Src Inhibitor
    PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl Learn More
  33. MLR 1023

    Catalog No. A12417
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    MLR 1023 is a selective allosteric activator of Lyn kinase (EC50 = 63 nM) Learn More
  34. KX2-391

    Catalog No. A11177
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    Src inhibitor

    KX2-391 is a novel non-ATP competitive substrate-pocket directed SRC inhibitor.

    Learn More
  35. PP121

    Catalog No. A11207
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    PI3K Inhibitor
    PP121 is a dual inhibitor of receptor tyrosine kinases (RTKs) (IC50 < 0.02 μM for Abl, Src, VEGFR-2 and PDGFR) and PI 3-K family kinases (IC50 < 0.06 μM for p110α, DNA-PK and mTOR). Learn More
  36. Quercetin (Sophoretin)

    Catalog No. A10766
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    MAO-B inhibitor
    Quercetin inhibits many enzyme systems including tyrosine protein kinase, phospholipase A2, phosphodiesterases, mitochondrial ATPase, PI 3-kinase and protein kinase C. Learn More
  37. XL-228

    Catalog No. A13069
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    IGF-1R, Aurora, FGFR, ABL, SRC inhibitor
    XL228 is a protein kinase inhibitor targeting IGF1R, the AURORA kinases, FGFR1-3, ABL and SRC family kinases. XL228 is an Aurora A inhibitor (IC50, f3 nmol/L) that has shown potent biochemical activity against ABL1 (Ki, 5 nmol/L), as well as the BCR-ABL1 T315I (Ki, 1.4 nmol/L) kinases. Learn More
  38. Lyn-IN-1

    Catalog No. A16265
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    dual Bcr-Abl/Lyn inhibitor
    Lyn-IN-1 is a potent and selective dual Bcr-Abl/Lyn inhibitor, extracted from patent WO2014169128A1. Learn More
  39. 1-NA-PP1

    Catalog No. A13232
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    Src Kinase inhibitor
    1-NA-PP1 is a selective inhibitor of v-Src and c-Fyn as well as c-Abl Learn More
  40. TC-S 7003 (Lck Inhibitor)

    Catalog No. A15140
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    Lck Inhibitor
    TC-S 7003 is a new class of compounds that are potent inhibitors of Lck with an IC50 value of 7 nM. Learn More
  41. Lck inhibitor 2

    Catalog No. A15141
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    Lck inhibitor
    Lck inhibitor 2 is a bis-anilinopyrimidine inhibitor of tyrosine kinases including LCK, BTK, LYN, SYK, and TXK. The IC50 values are 13nM, 9nM, 3nM, 26nM and 2nM for Lck, Btk, Lyn, Btk and Txk respectively . Learn More
  42. A-419259

    Catalog No. A13290
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    SFK inhibitor
    A-419259 trihydrochloride is an inhibitor of Src family kinases (SFK) (IC50 = 0.1 - 0.3 uM). Learn More
  43. TG 100801

    Catalog No. A13819
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    VEGFR2/Src inhibitor
    TG 100801 is a VEGFR2 targeting prodrug currently in a clinical trial. The active form is TG100572. Learn More
  44. TG 100572

    Catalog No. A13820
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    VEGFR2/Src inhibitor
    TG 100572 is VEGFR2 and Src kinase inhibitor. Learn More
  45. Scutellarein

    Catalog No. A12234
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    Scutellarin, a main active ingredient extracted from Erigeron breviscapus (Vant.) Hand-Mazz, has been wildly used to treat acute cerebral infarction and paralysis induced by cerebrovascular diseases. Learn More
  46. Tilfrinib

    Catalog No. A16086
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    Brk inhibitor
    Tilfrinib is a potent and selective breast tumor kinase (Brk) inhibitor (IC50 = 3.15 nM). Learn More
  47. CGP77675

    Catalog No. A13821
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    Src inhibitor
    CGP77675 is a potent Src kinase inhibitor. CGP77675 inhibited phosphorylation of peptide substrates and autophosphorylation of purified Src (IC50: 5-20 and 40 nM, respectively). Learn More
  48. PP1 Analog II, 1NM-PP1

    Catalog No. A13573
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    PP1 Analog II, 1NM-PP1 is a cell-permeable PP1 analog that acts as a potent and selective inhibitor of mutant kinases over their wild-type progenitors. Learn More
  49. CPDA

    Catalog No. A16242
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    SHIP2 inhibitor
    CPDA is a novel potent SHIP2 inhibitor that can effectively ameliorate insulin resistance in 3T3-L1 adipocytes. Learn More
  50. AMG-47a

    Catalog No. A13167
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    Lck inhibitor
    AMG-47a is an orally bioavailable potent inhibitor of Lck and T cell proliferation. It exhibits anti-inflammatory activity (ED50 11 mg/kg) in the anti-CD3 induced production of IL-2 in mice. Learn More

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