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$0.00 - Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Biological Activity
Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.
Targets
| Abl (Cell-free assay) | Src (Cell-free assay) | |||
| 1 nM | 1.2 nM |
| In vitro | DMSO | 100 mg/mL (188.51 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 2 mg/mL (3.77 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 18.85 mL | 94.27 mL | 188.54 mL |
| 0.5 mM | 3.77 mL | 18.85 mL | 37.71 mL |
| 1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
| 5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A10161 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 530.4 |
| Formula | C26H29Cl2N5O3 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 380843-75-4 |
| Synonyms | SKI-606, SKI606 |
| SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
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