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- Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961
Biological Activity
Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.
Targets
Abl (Cell-free assay) | Src (Cell-free assay) | |||
1 nM | 1.2 nM |
In vitro (25°C) | DMSO | 93 mg/mL (175.31 mM) | |
Water | Insoluble | ||
Ethanol | 2 mg/mL (3.77 mM) | ||
In vivo | 2% DMSO+30% PEG 300+5% Tween 80+ddH2O | 9 mg/mL | |
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
---|---|---|---|
0.1 mM | 18.85 mL | 94.27 mL | 188.54 mL |
0.5 mM | 3.77 mL | 18.85 mL | 37.71 mL |
1 mM | 1.89 mL | 9.43 mL | 18.85 mL |
5 mM | 0.38 mL | 1.89 mL | 3.77 mL |
*The above data is based on the productmolecular weight 530.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
Catalog Num | A10161 |
---|---|
Actions | Inhibitor |
CAS No. | 380843-75-4 |
Formula | C26H29Cl2N5O3 |
M. Wt | 530.4 |
Purity | >98% |
Synonyms | SKI-606, SKI606 |
SMILES | CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC |
Storage | Store lyophilized at -20ºC, keep desiccated. |
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