Bosutinib (SKI-606)

Catalog No.: A10161

Src inhibitor

Bosutinib (SKI-606)

Bosutinib (SKI-606) Chemical Structure

CAS NO. 380843-75-4

Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.

Availability: In stock

Package Price Qty
10 mg

Regular Price: $55.00

Special Price $44.00

50 mg

Regular Price: $108.00

Special Price $86.40

100 mg

Regular Price: $162.00

Special Price $129.60

200 mg

Regular Price: $195.00

Special Price $156.00

10mM * 1mL in DMSO

Regular Price: $88.00

Special Price $70.40

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Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.
  • Li Li, .et al. Evidence for activated Lck protein tyrosine kinase as the driver of proliferation in acute myeloid leukemia cell, CTV-1, Leukemia Res, 2019, 78:12-20 PMID: 30660961

Biological Activity

Bosutinib (SKI-606) is a tyrosine kinase inhibitor undergoing research for use in the treatment of cancer.
Targets
Abl (Cell-free assay) Src (Cell-free assay)
1 nM1.2 nM
In vitro (25°C) DMSO 93 mg/mL (175.31 mM)
Water Insoluble
Ethanol 2 mg/mL (3.77 mM)
In vivo 2% DMSO+30% PEG 300+5% Tween 80+ddH2O 9 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 18.85 mL 94.27 mL 188.54 mL
0.5 mM 3.77 mL 18.85 mL 37.71 mL
1 mM 1.89 mL 9.43 mL 18.85 mL
5 mM 0.38 mL 1.89 mL 3.77 mL

*The above data is based on the productmolecular weight 530.4 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A10161
Actions Inhibitor
CAS No. 380843-75-4
Formula C26H29Cl2N5O3
M. Wt 530.4
Purity >98%
Synonyms SKI-606, SKI606
SMILES CN1CCN(CC1)CCCOC2=C(C=C3C(=C2)N=CC(=C3NC4=CC(=C(C=C4Cl)Cl)OC)C#N)OC
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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