PP1

Catalog No.: A12724

Src Inhibitor

PP1 Chemical Structure

CAS NO. 172889-26-8

PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl

Availability: In stock

Package Price Qty
10 mg
$100.00
25 mg
$220.00
50 mg
$320.00
100 mg
$500.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PP1 is a potent inhibitor of Src-family tyrosine kinases. Inhibits p56lck and p59fynT (IC50 values are 5 and 6 nM respectively). Displays > 8000-fold selectivity over ZAP-70 and JAK2. Also moderately inhibits p38, CSK, PDGF receptors, RET-derived oncoproteins, c-Kit and Bcr-Abl
Targets
Target Value
LCKIC50: 5nM
FynIC50: 6nM
KitIC50: ~75nM
EGFRIC50: 250nM
Bcr-AblIC50: 1μM
JAK2IC50: >50μM
ZAP70IC50: >100μM
In vitro DMSO 4 mg/mL (14.21 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.54 mL 177.71 mL 355.42 mL
0.5 mM 7.11 mL 35.54 mL 71.08 mL
1 mM 3.55 mL 17.77 mL 35.54 mL
5 mM 0.71 mL 3.55 mL 7.11 mL

*The above data is based on the productmolecular weight 281.36. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A12724
Actions Inhibitor
M. Wt 281.36
Formula C16H19N5
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 172889-26-8
Synonyms PP-1, PP 1
SMILES CC1=CC=C(C=C1)C2=NN(C3=C2C(=NC=N3)N)C(C)(C)C

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