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Cycloguanil-d4 (hydrochloride)

Stable Isotope

Cycloguanil-d4 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, serving as a stable isotope for research applications. This compound functions as a dihydrofolate reductase (DHFR) inhibitor, with an IC50 of 10.8 μM against human DHFR, and effectively disrupts the folate metabolic pathway, which is critical for nucleotide synthesis and DNA replication. Cycloguanil-d4 is utilized in malaria research due to its ability to inhibit DHFR in Plasmodium species and is also recognized for its potential anticancer activities, as it inhibits DHFR in human cancer cells and blocks transcriptional activity of STAT3.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	1189427-23-3
Applications	Stable Isotope
Formula	C₁₁H₁₁D₄Cl₂N₅
Molecular Weight	292.20
Synonyms	Chlorguanide triazine-d4 (hydrochloride)
SMILES	CC1(N(C2=C([2H])C([2H])=C(C([2H])=C2[2H])Cl)C(N)=NC(N)=N1)C.Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.