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Cycloguanil-d6 (hydrochloride)

Stable Isotope

Cycloguanil-d6 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, a potent inhibitor of dihydrofolate reductase (DHFR). With an IC50 of 10.8 μM against human DHFR, this stable isotope disrupts the folate metabolic pathway, leading to impaired nucleotide synthesis and DNA replication. Cycloguanil-d6 (hydrochloride) is utilized in malaria research due to its efficacy against Plasmodium DHFR, and it demonstrates significant potential in cancer research by inhibiting DHFR in human cancer cells and blocking STAT3 transcriptional activity.

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Specifications

Manufacturer	Adooq Bioscience
CAS Number	2712364-69-5
Applications	Stable Isotope
Formula	C₁₁H₉D₆Cl₂N₅
Molecular Weight	294.21
Synonyms	Chlorguanide triazine-d6 (hydrochloride)
SMILES	[2H]C([2H])([2H])C1(N(C2=CC=C(C=C2)Cl)C(N)=NC(N)=N1)C([2H])([2H])[2H].Cl

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.