Cycloguanil-d6 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, a potent inhibitor of dihydrofolate reductase (DHFR). With an IC50 of 10.8 μM against human DHFR, this stable isotope disrupts the folate metabolic pathway, leading to impaired nucleotide synthesis and DNA replication. Cycloguanil-d6 (hydrochloride) is utilized in malaria research due to its efficacy against Plasmodium DHFR, and it demonstrates significant potential in cancer research by inhibiting DHFR in human cancer cells and blocking STAT3 transcriptional activity.
Cycloguanil-d6 (hydrochloride) is a deuterium-labeled derivative of Cycloguanil, a potent inhibitor of dihydrofolate reductase (DHFR). With an IC50 of 10.8 μM against human DHFR, this stable isotope disrupts the folate metabolic pathway, leading to impaired nucleotide synthesis and DNA replication. Cycloguanil-d6 (hydrochloride) is utilized in malaria research due to its efficacy against Plasmodium DHFR, and it demonstrates significant potential in cancer research by inhibiting DHFR in human cancer cells and blocking STAT3 transcriptional activity.
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