Fig. 1 · Structure
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Trimetazidine-d8 dihydrochloride
Stable Isotope
Trimetazidine-d8 dihydrochloride is a deuterium-labeled form of Trimetazidine, which selectively inhibits long-chain 3-ketoyl coenzyme A thiolase with an IC50 of 75 nM, effectively blocking β-oxidation of free fatty acids. It functions as an antianginal and cytoprotective agent, exhibiting antioxidant, anti-inflammatory, antinociceptive, and gastroprotective properties. Additionally, Trimetazidine-d8 dihydrochloride activates autophagy and inhibits 3-hydroxyacyl-CoA dehydrogenase (HADHA), making it a crucial tool for research into cellular metabolism and cardiac function.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1219795-37-5 |
| Applications | Stable Isotope |
| Formula | C14H16D8Cl2N2O3 |
| Molecular Weight | 347.31 |
| SMILES | COC1=C(CN2C([2H])(C([2H])(NC([2H])(C2([2H])[2H])[2H])[2H])[2H])C=CC(OC)=C1OC.Cl.Cl |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.