Fig. 1 · Structure
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Niclosamide-13C6
Stable Isotope
Niclosamide-13C6 is a stable isotope-labeled form of Niclosamide, a chlorinated salicylanilide known for its anthelmintic properties and potential antitumor activity. This compound functions primarily by inhibiting the Signal Transducer and Activator of Transcription 3 (STAT3) with an IC50 of 0.25 μM in HeLa cells, subsequently affecting DNA replication in vitro. Niclosamide-13C6 is useful in biological studies that require isotope tracking and quantification of drug metabolism and efficacy in cancer research.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1325808-64-7 |
| Applications | Stable Isotope |
| Formula | C713C6H8Cl2N2O4 |
| Molecular Weight | 333.08 |
| Synonyms | BAY2353-13C6 |
| SMILES | O=C(N[13C]1=[13CH][13CH]=[13C]([N+]([O-])=O)[13CH]=[13C]1Cl)C2=CC(Cl)=CC=C2O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.