Fig. 1 · Structure
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Ivacaftor-d18
Stable Isotope
Ivacaftor-d18 is the deuterated form of Ivacaftor, a selective CFTR potentiator. It effectively targets G551D-CFTR and F508del-CFTR, demonstrating EC50 values of 100 nM and 25 nM, respectively. This stable isotope is essential for research applications related to cystic fibrosis, providing a tool for in vivo studies and pharmacokinetic analyses.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1413431-05-6 |
| Applications | Stable Isotope |
| Formula | C24H10D18N2O3 |
| Molecular Weight | 410.60 |
| Synonyms | VX-770-d18 |
| SMILES | [2H]C([2H])([2H])C(C([2H])([2H])[2H])(C1=C(C=C(C(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=C1)O)NC(C2=CNC3=CC=CC=C3C2=O)=O)C([2H])([2H])[2H] |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.