Fig. 1 · Structure
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Topotecan-d6
Stable Isotope
Topotecan-d6 is a deuterated form of Topotecan, a potent inhibitor of Topoisomerase I, which plays a critical role in DNA replication and repair. This compound exhibits significant biological activity, with IC50 values of approximately 2.73 μM in U251 cells, 2.95 μM in U87 cells, and ranging from 5.46 to 5.95 μM in glioblastoma stem cells (GSCs-U251 and GSCs-U87). Topotecan-d6 is ideal for studies involving drug metabolism, pharmacokinetics, and cancer research, particularly in understanding the mechanisms of action of Topoisomerase I inhibitors.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1044904-10-0 |
| Applications | Stable Isotope |
| Formula | C23H17D6N3O5 |
| Molecular Weight | 427.48 |
| SMILES | CC[C@@]1(C2=C(COC1=O)C(N3C(C(C(C3)=CC4=C5CN(C([2H])([2H])[2H])C([2H])([2H])[2H])=NC4=CC=C5O)=C2)=O)O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.