Fig. 1 · Structure
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Pyrazinamide-d3
Stable Isotope
Pyrazinamide-d3 is a deuterium-labeled form of the antitubercular antibiotic pyrazinamide. This compound functions as a prodrug, which is metabolically converted to its active form, pyrazinoic acid (POA), by the enzyme nicotinamidase/PZase, encoded by the pncA gene in Mycobacterium tuberculosis. Pyrazinamide-d3 is utilized in metabolic studies and tracer experiments to investigate tuberculosis drug metabolism and efficacy. Its stable isotope labeling aids in the quantification and analysis of pyrazinamide’s pharmacokinetics in biological systems.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1432059-16-9 |
| Applications | Stable Isotope |
| Formula | C5H2D3N3O |
| Molecular Weight | 126.13 |
| Synonyms | Pyrazinecarboxamide-d3; Pyrazinoic acid amide-d3 |
| SMILES | NC(C1=NC([2H])=C([2H])N=C1[2H])=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.