Fig. 1 · Structure
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Clarithromycin-d3
Stable Isotope
Clarithromycin-d3 is a deuterium-labeled derivative of Clarithromycin, primarily used as a stable isotope. Clarithromycin exhibits a broad spectrum of antimicrobial activity and inhibits the CYP3A4-mediated alpha-hydroxylation of triazolam, showing an IC50 value of 56 μM. Additionally, it significantly affects hERG potassium currents and disrupts autophagic flux by interfering with the signaling pathway between hERG1 and PI3K. This reagent is valuable for research applications involving drug metabolism, ion channel activity, and cellular signaling pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 959119-22-3 |
| Applications | Stable Isotope |
| Formula | C38H66D3NO13 |
| Molecular Weight | 750.97 |
| SMILES | C[C@@](OC)(C[C@H](C([C@@H]1C)=O)C)[C@@H]([C@H]([C@@H]([C@H](C(O[C@H](CC)[C@@](C)(O)[C@@H]1O)=O)C)O[C@@](O[C@@H](C)[C@@H]2O)([H])C[C@@]2(C)OC)C)O[C@@](O[C@H](C)C[C@@H]3N(C([2H])([2H])[2H])C)([H])[C@@H]3O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.