Fig. 1 · Structure
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Glyburide-d11
Stable Isotope
Glyburide-d11 is a deuterium-labeled analog of Glibenclamide, primarily acting as an ATP-sensitive K+ channel (KATP) inhibitor. It plays a crucial role in diabetes and obesity research by inhibiting P-glycoprotein and blocking the SUR1 subunits of KATP. Furthermore, Glyburide-d11 affects mitochondrial bioenergetics by altering membrane ion permeability and can induce autophagy, making it a valuable tool for studying cellular metabolism and drug response.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1189985-02-1 |
| Applications | Stable Isotope |
| Formula | C23H17D11ClN3O5S |
| Molecular Weight | 505.07 |
| SMILES | [2H]C1([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C([2H])([2H])C1([2H])NC(NS(C(C=C2)=CC=C2CCNC(C3=C(C=CC(Cl)=C3)OC)=O)(=O)=O)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.