Fig. 1 · Structure
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Retinoic acid-d6
Stable Isotope
Retinoic acid-d6 is a deuterium-labeled derivative of retinoic acid, a crucial metabolite of vitamin A. It functions primarily as an agonist of retinoic acid receptors (RAR), exhibiting IC50 values of 14 nM for RARα, RARβ, and RARγ. Additionally, retinoic acid-d6 binds to PPARβ/δ with a Kd of 17 nM and inhibits the transcription factor Nrf2 through the activation of retinoic acid receptor alpha. This compound is valuable for studies involving cellular growth, differentiation, and organogenesis, as well as for investigating the regulatory mechanisms of nuclear receptors in research applications.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 2483831-72-5 |
| Applications | Stable Isotope |
| Formula | C20H22D6O2 |
| Molecular Weight | 306.47 |
| Synonyms | Vitamin A acid-d6; all-trans-Retinoic acid-d6; ATRA-d6 |
| SMILES | OC(/C=C(C([2H])([2H])[2H])/C=C/C=C(C([2H])([2H])[2H])/C=C/C1=C(C)CCCC1(C)C)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.