Fig. 1 · Structure
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Letrozole-d4
Stable Isotope
Letrozole-d4 is a deuterium-labeled analogue of Letrozole, a selective non-steroidal aromatase inhibitor. It effectively inhibits estrogen biosynthesis with an IC50 of 11.5 nM, making it a valuable tool for studying the mechanisms of estrogen-dependent tumor growth in breast cancer research. This stable isotopic variant facilitates advanced metabolic studies and pharmacokinetic analyses in various experimental settings.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1133712-96-5 |
| Applications | Stable Isotope |
| Formula | C17H7D4N5 |
| Molecular Weight | 289.33 |
| SMILES | C(C1=C(C(=C(C#N)C(=C1[2H])[2H])[2H])[2H])(C2=CC=C(C#N)C=C2)N3C=NC=N3 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.