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IκB/IKK Inhibitor

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Catalog No. A12746

Availability:Stock in USAIn stock

Product Name Catalog No. Price Qty
SC-514 10mg A12746-10

Regular Price: €38.00

Special Price: €34.20

SC-514 25mg A12746-25

Regular Price: €76.00

Special Price: €68.40

SC-514 50mg A12746-50

Regular Price: €123.50

Special Price: €111.15

SC-514 100mg A12746-100

Regular Price: €190.00

Special Price: €171.00

SC-514 10mM * 1mL in DMSO A12746-10mM-D

Regular Price: €64.60

Special Price: €58.14

Products are for laboratory research use only. Not for human use. We do not sell to patients.

Quick Overview

SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.


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Chemical Information

Catalog Num A12746
Actions Inhibitor
M. Wt 224.3
Formula C9H8N2OS2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 354812-17-2
Synonyms SC514, SC 514

Biological Activity

SC-514 is an orally active, ATP-competitive IKKβ inhibitor (IC50 = 3 - 12 μM) that displays > 10-fold selectivity over 28 other kinases including JNK, p38, MK2 and ERK.
Target Value
IKK2IC50: 3μM-12μM
CDK2/CyclinAIC50: 61μM
AUR2IC50: 71μM
PRAKIC50: 75μM
p38αIC50: >100μM
p38βIC50: >100μM
p38γIC50: >100μM
p38δIC50: >100μM
ERK2IC50: >100μM
GSK-3IC50: >100μM
NIM1IC50: >100μM
Chk1IC50: >100μM
PAK5IC50: >100μM
PKAIC50: >100μM
PKCβIC50: >100μM
LynIC50: >100μM
FGFR1IC50: >100μM
EGFRIC50: >100μM
LCKIC50: >100μM
c-AblIC50: >100μM
MSKIC50: 123μM
JNK1IC50: >200μM
JNK2IC50: >200μM
JNK3IC50: >200μM
MK2IC50: >200μM
MK3IC50: >200μM
RSKBIC50: >200μM
MKK7IC50: >200μM


Solubility (25°C)* In vitro DMSO 45 mg/mL (200.62 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 44.58 mL 222.92 mL 445.83mL
0.5 mM 8.92 mL 44.58 mL 89.17 mL
1 mM 4.46 mL 22.29 mL 44.58 mL
5 mM 0.89 mL 4.46 mL 8.92 mL

*The above data is based on the productmolecular weight 224.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

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