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$0.00 - Anton Lennikov, .et al. Selective IKK2 inhibitor IMD0354 disrupts NF-κB signaling to suppress corneal inflammation and angiogenesis, Angiogenesis, 2018, 21(2): 267-285 PMID: 29332242
Biological Activity
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
Targets
| IKKβ | ||||
| In vitro (25°C) | DMSO | 10 mg/mL (26.06 mM) | |
| Water | <1 mg/mL (<1 mM) | ||
| Ethanol | 77 mg/mL (200.69 mM) | ||
| In vivo | 0.5% CMC/0.25% Tween 80, pH 4 | 10 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.06 mL | 130.32 mL | 260.64 mL |
| 0.5 mM | 5.21 mL | 26.06 mL | 52.13 mL |
| 1 mM | 2.61 mL | 13.03 mL | 26.06 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.21 mL |
*The above data is based on the productmolecular weight 383.67. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12837 |
|---|---|
| Actions | Inhibitor |
| M. Wt | 383.67 |
| Formula | C15H8ClF6NO2 |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 3 years Powder |
| CAS No. | 978-62-1 |
| Synonyms | IMD-0354, IMD0354 |
| SMILES | C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O |
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