IMD 0354
IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation.
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Biological Activity
| Discription | IMD 0354 is an inhibitor of IκB kinase-β (IKKβ) that blocks NF-κB nuclear translocation. | ||
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Product Information
| Catalog Num | A12837 |
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| Formula | C15H8ClF6NO2 |
| Molecular Weight | 383.67 |
| CAS Number | 978-62-1 |
| SMILES | C1=CC(=C(C=C1Cl)C(=O)NC2=CC(=CC(=C2)C(F)(F)F)C(F)(F)F)O |
| Synonyms | IMD-0354, IMD0354 |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
Solubility
| In vitro (25°C) | DMSO | 9 mg/mL (23.45 mM) | |
| Water | Insoluble | ||
| Ethanol | 72 mg/mL (187.66 mM) | ||
| In vivo | 2% DMSO+5% Tween 80+0.5% CMC Na | 2 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.06 mL | 130.32 mL | 260.64 mL |
| 0.5 mM | 5.21 mL | 26.06 mL | 52.13 mL |
| 1 mM | 2.61 mL | 13.03 mL | 26.06 mL |
| 5 mM | 0.52 mL | 2.61 mL | 5.21 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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