TPCA-1

TPCA-1 Chemical Structure

CAS NO. 507475-17-4

TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.

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Package Price Qty
10 mg

Regular Price: $120.00

Special Price $108.00

25 mg

Regular Price: $250.00

Special Price $225.00

50 mg

Regular Price: $420.00

Special Price $378.00

100 mg

Regular Price: $700.00

Special Price $630.00

10mM * 1mL in DMSO

Regular Price: $93.00

Special Price $83.70

Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
Targets
IKK2 (Cell-free assay)
17.9 nM
In vitro (25°C) DMSO 56 mg/mL (200.5 mM)
Water <1 mg/mL (<1 mM)
Ethanol <1 mg/mL (<1 mM)
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 15 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.03 mL 358.05 mL
0.5 mM 7.16 mL 35.81 mL 71.61 mL
1 mM 3.58 mL 17.9 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL

*The above data is based on the productmolecular weight 279.29. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Chemical Properties

Catalog Num A11579
Actions Inhibitor
M. Wt 279.29
Formula C12H10FN3O2S
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 507475-17-4
Synonyms TPCA1
SMILES C1=CC(=CC=C1C2=CC(=C(S2)NC(=O)N)C(=O)N)F

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