Catalog No.: A11579
IKK-2 inhibitor
TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
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TPCA-1 10mg
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TPCA-1 25mg
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TPCA-1 50mg
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TPCA-1 100mg
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TPCA-1 10mM * 1mL in DMSO
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Biological Activity
Discription TPCA-1 is a potent and selective inhibitor of human IκB kinase-2 (IKK-2) with IC50 = 17.9 nM for IKK-2 compared to 400nm for IKK-1.
Target Value
Product Information
Catalog Num A11579
Formula C12H10FN3O2S
Molecular Weight 279.29
CAS Number 507475-17-4
Synonyms TPCA1

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

In vitro (25°C) DMSO 49 mg/mL (175.44 mM)
Water Insoluble
Ethanol Insoluble
In vivo 2% Cremophor EL, 2% N,N-dimethylacetamide 14 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
Preparing Stock Solutions
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 35.81 mL 179.03 mL 358.05 mL
0.5 mM 7.16 mL 35.81 mL 71.61 mL
1 mM 3.58 mL 17.9 mL 35.81 mL
5 mM 0.72 mL 3.58 mL 7.16 mL
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