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- Byungki Jang, .et al. The Peptidylarginine Deiminase Inhibitor Cl-Amidine Suppresses Inducible Nitric Oxide Synthase Expression in Dendritic Cells, Int J Mol Sci, 2017, Nov; 18(11): 2258 PMID: 29077055
Biological Activity
BAY 11-7085 is an irreversible inhibitor of TNFα-induced IκBα phosphorylation with IC50 of 10 μM
Targets
| IκBα?phosphorylation | ||||
| 10 μM |
| In vitro | DMSO | 49 mg/mL (196.52 mM) | |
| Water | Insoluble | ||
| Ethanol | 49 mg/mL (196.52 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 40.11 mL | 200.54 mL | 401.07 mL |
| 0.5 mM | 8.02 mL | 40.11 mL | 80.21 mL |
| 1 mM | 4.01 mL | 20.05 mL | 40.11 mL |
| 5 mM | 0.8 mL | 4.01 mL | 8.02 mL |
*The above data is based on the productmolecular weight 249.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| Catalog Num | A12470 |
|---|---|
| Actions | Inhibitor |
| CAS No. | 196309-76-9 |
| Formula | C13H15NO2S |
| M. Wt | 249.33 |
| Purity | >98% |
| Synonyms | Bay 11-7083, BAY11-7085 |
| SMILES | CC(C)(C)C1=CC=C(C=C1)S(=O)(=O)/C=C/C#N |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
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