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Fig. 1 · Structure
Cat. No.
A16299
CAS No.
932730-51-3
Formula
C33H46N2O3
Mol. Weight
518.73

Documents & Downloads

CDDO-EA

Cat. No. A16299 CAS 932730-51-3

Nrf2 activator

CDDO-EA is an activator of Nrf2/ARE; Neuroprotective effect.

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For laboratory research use only. We do not sell to patients.

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Biological Activity

Cellular Effect

Cell Line Activity Value Description Reference
HT-29 EC50 1.38 μM Anti-necroptotic activity in human HT-29 cells assessed as inhibition of TNFalpha/SM-164/Z-VAD-fmk (TSZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay [PMID: 33248849]
L929 EC50 4.15 μM Anti-necroptotic activity in mouse L929 cells assessed as inhibition of TNFalpha/Z-VAD-fmk (TZ)-induced necroptosis by measuring increase in cell viability measured after 12 hrs by celltiter-glo luminescent cell viability assay [PMID: 33248849]

Specifications

Manufacturer Adooq Bioscience
Actions Activator
CAS Number 932730-51-3
Applications Nrf2 activator
Formula C33H46N2O3
Molecular Weight 518.73
Synonyms CDDO ethyl amide; RTA405; TP319
SMILES
CCNC(=O)C12CCC(CC1C3C(=O)C=C4C(C3(CC2)C)(CCC5C4(C=C(C(=O)C5(C)C)C#N)C)C)(C)C

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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