Fig. 1 · Structure
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PROTAC IKKβ/NR4A1 degrader-1
Cat. No.
A25211
CAS
2826215-20-5
PROTAC IKKβ/NR4A1 Degrader
PROTAC IKKβ/NR4A1 degrader-1 is a novel dual-PROTAC degrader designed to selectively target and degrade IKKβ and NR4A1, utilizing the E3 ligase cereblon. This compound effectively increases the levels of caspase 3 and cleaved caspase 3 proteins, indicating a potential to induce apoptosis without affecting the necroptosis marker RIP kinase. It is a valuable tool for investigating the mechanisms underlying Acute Myeloid Leukemia (AML) and offers insights into therapeutic strategies targeting these pathways.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Degrader |
| CAS Number | 2826215-20-5 |
| Applications | PROTAC IKKβ/NR4A1 Degrader |
| Formula | C48H60N4O7 |
| Molecular Weight | 805.01 |
| SMILES | [H][C@@]12C[C@](C(NCCCCCCNC3=CC=CC4=C3C(N(C4=O)C5CCC(NC5=O)=O)=O)=O)(CC[C@@]1(CC[C@@]6(C7=CC=C8C([C@@]7(CC[C@]62C)C)=CC(C(O)=C8C)=O)C)C)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.