PHA 408

Catalog No.: A13108

IKK-2 inhibitor

PHA 408

PHA 408 Chemical Structure

CAS NO. 503555-55-3

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.

Availability: In stock

Package Price Qty
5 mg
$120.00
10 mg
$220.00
25 mg
$450.00
50 mg
$750.00
Warning Products are for laboratory research use only. Not for human use. We do not sell to patients.

Biological Activity

PHA 408 is a potent, highly selective and ATP-competitive IKB kinase-2 (IKK-2) inhibitor (IC50: 40 nM), which binds IKK-2 tightly with a relatively slow off rate; highly recommended tool to investigate the mechanisms by which IKK-2 regulates NF-KB signaling.
Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 17.86 mL 89.28 mL 178.57 mL
0.5 mM 3.57 mL 17.86 mL 35.71 mL
1 mM 1.79 mL 8.93 mL 17.86 mL
5 mM 0.36 mL 1.79 mL 3.57 mL

*The above data is based on the productmolecular weight 560.02. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

Catalog Num A13108
Actions Inhibitor
M. Wt 560.02
Formula C29H27ClFN7O2
Solubility DMSO
Purity >98%
Storage at -20°C 3 years Powder
CAS No. 503555-55-3
Synonyms PHA-408, PHA408
SMILES CN1CCN(CC1)C2=NC=C(C(=C2)C(=O)NC3=CC4=C(CCC5=C4N(N=C5C(=O)N)C6=CC=C(C=C6)F)C=C3)Cl

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