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Proteases

Items 51-100 of 1366

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Product Name
Application
Product Information
Citations
  1. A12373
    Z-VAD-FMK

    Pan Caspase Inhibitor

    Z-VAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor. Inhibits caspase processing and apoptosis induction in tumor cells in vitro (IC50 = 0.0015 - 5.8 mM). Active in vivo.
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  2. A11985
    Amprenavir
    Amprenavir is an human immunodeficiency virus (HIV) protease inhibitor with IC50 of 14.6 ?? 12.5 ng/ml for wild-type HIV isolates
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  3. A14073
    Sivelestat sodium salt

    Neutrophil elastase inhibitor

    Sivelestat sodium salt is a selective leukocyte elastase inhibitor (IC50 = 44 nM) that displays no activity at a range of other proteases. It inhibits NF-kB activation and LTB4-induced neutrophil transmigration in vitro.
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  4. A11336
    BMS-790052 2HCl

    NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  5. A14100
    Nivocasan (GS-9450)

    Caspase inhibitor

    Nivocasan is a novel caspase-inhibitor has demonstrated hepatoprotective activity in fibrosis/apoptosis animal models.
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  6. A10600
    MLN2238 (Ixazomib)

    Proteasome Inhibitor

    MLN2238 is a potent reversible and specific β5 site of the 20S proteasome inhibitor with an IC50 value of 3.4 nM.
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  7. A13815
    FLI-06

    Gamma-secretase inhibitor

    FLI-06 is a Notch inhibitor and the early secretory pathway inhibitor. FLI-06 disrupts the Golgi apparatus in a manner distinct from that of brefeldin A and golgicide A.
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  8. A10138
    BIBR 953 (Dabigatran, Pradaxa)

    Thrombin inhibitor

    BIBR 953 (Dabigatran, Pradaxa) is a highly selective, reversible, and potent thrombin inhibitor and is orally available as the prodrug, dabigatran etexilate. It has shown antithrombotic efficacy in animal models of thrombosis, with a rapid onset of action and predictable pharmacodynamic response.

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  9. A13853
    Marizomib (NPI-0052, salinosporamide A)

    Proteasome Inhibitor

    Marizomib is a naturally-occurring salinosporamide, isolated from the marine actinomycete Salinospora tropica, with potential antineoplastic activity.
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  10. A13256
    CA-074

    Cathepsin B inhibitor

    CA-074 is a potent inhibitor of cathepsin B with a Ki of 2 to 5 nM.
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  11. A19622
    KP-457

    ADAM17 inhibitor

    KP-457 is a selective a disintegrin and metalloproteinase 17 (ADAM17) inhibitor, with higher selectivity for ADAM17 than for other MMPs and ADAM10, and IC50s are 11.1 nM (ADAM17), 748 nM (ADAM10), 717 nM (MMP2), 9760 nM (MMP3), 2200 nM (MMP8), 5410 nM (MMP9), 930 nM (MMP13), 2140 nM (MMP14), and 7100 nM (MMP17), respectively.
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  12. A10159
    BMS-790052 (Daclatasvir)

    HCV NS5A inhibitor

    BMS-790052 is an NS5A inhibitor under investigation for the treatment of hepatitis C virus (HCV) infection.
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  13. A10288
    DAPT (GSI-IX)

    Gamma secretase inhibitor

    DAPT (GSI-IX) is an inhibitor of γ-secretase that causes a reduction in Aβ40 and Aβ42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Aβ and Aβ42 respectively.
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  14. A11332
    Boceprevir (SCH-503034)

    HCV Protease Inhibitor

    Boceprevir is a protease inhibitor used as a treatment for hepatitis C genotype 1.
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  15. A10980
    Cis-Lomibuvir (cis-VX-222)

    HCV Protease inhibitor

    VX-222 is a small molecule non-nucleoside inhibitor of HCV NS5B polymerase that is being investigated for the treatment of hepatitis C virus infection.
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  16. A11174
    YO-01027

    γ-secretase inhibitor

    YO-01027 is a dipeptidic γ-secretase inhibitor, an antiAlzheimer agent.
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  17. A15292
    ARP 100

    MMP-2 inhibitor

    ARP 100 is a selective inhibitor of matrix metalloproteinases 2 (MMP-2) with IC50 value of 12 nM.
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  18. A11901
    PMSF

    Serine/cysteine protease inhibitor

    PMSF is an irreversible serine/cysteine protease inhibitor.
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  19. A14263
    Aprotinin

    serine protease inhibitor

    Aprotinin is a small protein serine protease inhibitor, used to reduce perioperative blood loss and transfusion.
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  20. A10984
    VX-765 (Belnacasan)

    Caspase-1/4 inhibitor

    VX-765 is a novel Caspase-1 inhibitor,which is an enzyme that controls the generation of two cytokines, IL-1b and IL-18.
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  21. A11393
    E 2012

    gamma-secretase modulator

    E 2012 is γ-secretase inhibitor.
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  22. A10836
    Semagacestat (LY450139)

    Gamma-secretase inhibitor

    Semagacestat (LY450139) is a γ-secretase blocker for Aβ42, Aβ40 and Aβ38 with IC50 of 10.9 nM, 12.1 nM and 12.0 nM, respectively. Semagacestat also inhibits Notch signaling with IC50 of 14.1 nM.
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  23. A13070
    LY573636 (Tasisulam)

    Apoptosis inducer

    LY573636 is a potent anti-tumor agent, which causes growth arrest and apoptosis of a variety of human solid tumors in vitro and in vivo. LY573636-induced apoptosis occurs by a mitochondrial-targeted mechanism.
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  24. A15300
    Ivachtin

    Caspase-3 inhibitor

    Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of Caspase-3 (IC50 = 23 nM).
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  25. A10617
    Nafamostat mesylate

    serine protease inhibitor

    Nafamostat is an anticoagulant. Broad spectrum serine protease inhibitor. Reduces eosinophil infiltration, mast cell activation and airway responsiveness in a murine model of asthma.
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  26. A14377
    Sitagliptin

    DDP-4 inhibitor

    Sitagliptin is an oral antihyperglycemic (anti-diabetic drug) of the dipeptidyl peptidase-4 (DPP-4) inhibitor class.
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  27. A12304
    D-erythro-Sphingosine

    p32-kinase activator

    D-erythro-Sphingosine (Erythrosphingosine) is a very potent activator of p32-kinase with an EC50 of 8 μM, and inhibits protein kinase C (PKC). D-erythro-Sphingosine (Erythrosphingosine) is also a PP2A activator.
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  28. A12374
    VCH-916

    HCV NS5B polymerase inhibitor

    VCH-916 is a novel nonnucleoside HCV NS5B polymerase inhibitor.
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  29. A12433
    Flurizan

    gamma-secretase modulator

    Flurizan is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits γ-secretase activity.
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  30. A12487
    L-873724

    Cathepsin K inhibitor

    L-873724 is a potent, orally bioavailable, selective and reversible non-basic cathepsin K inhibitor.
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  31. A12499
    MBM-17

    Nek2 inhibitor

    MBM-17 (compound 42c) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 3 nM.
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  32. A12509
    Ximelagatran

    Thrombin inhibitor

    Ximelagatran is an anticoagulant that has been investigated extensively as a replacement for warfarin that would overcome the problematic dietary, drug interaction, and monitoring issues associated with warfarin therapy.
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  33. A12510
    MBM-55

    Nek2 inhibitor

    MBM-55 (compound 42g) is a potent NIMA-related kinase 2 (Nek2) inhibitor with an IC50 of 1 nM.
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  34. A12583
    Fosamprenavir

    HIV protease inhibitor

    Fosamprenavir is a prodrug of amprenavir, an inhibitor of human immunodeficiency virus (HIV) protease.
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  35. A12611
    Z-VEID-FMK

    Caspase-6 inhibitor

    Z-VEID-FMK is the specific recognition sequence for caspase-6/Mch2. Z-VEID-FMK is a synthetic peptide that irreversibly inhibits activity of VEID-dependent caspases (e.g., caspase-6). The inhibitor is designed as a methyl ester to facilitate cell permeability.
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  36. A12637
    Z-VDVAD-FMK

    Caspase-2 inhibitor

    Z-VDVAD-FMK is a cell-permeable, irreversible inhibitor of caspase-2. Caspase inhibitors play an important role in investigating biological processes.
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  37. A12791
    Sephin1 (Icerguastat)

    PPP1R15A inhibitor

    Sephin1 is a selective inhibitor of stress-induced PPP1R15A and targets disease associated with accumulation of misfolded protein.
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  38. A12809
    2-MPPA

    GCP-II inhibitor

    2-MPPA is a selective glutamate carboxypeptidase II (GCP-II) inhibitor used in the treatment of neurological disorders associated with excessive activation of glutamatergic systems. Attenuates glutamate transmission resulting in the relief of neuropathic pain.
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  39. A12817
    3AC (3α-Aminocholestane)

    SHIP1 Inhibitor

    3AC is a cell-permeable, selective inhibitor of SHIP1 polyphosphatase activity toward PIP3 (IC50 = 10 μM), but has no effect on SHIP2 or PTEN activity on PIP3.
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  40. A12848
    4-epi-Chlortetracycline Hydrochloride

    MMP inhibitor

    4-epi-Chlortetracycline Hydrochloride is a tetracycline derivative that acts as a metalloproteinase (MMP) inhibitor, used in treating tissue destructive diseases and cancer
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  41. A12853
    T-26c

    matrix metalloproteinase-13 (MMP-13) inhibitor

    T-26c is highly potent and selective matrix metalloproteinase-13 (MMP-13) inhibitor with an IC50 of 6.75 pM and more than 2600-fold selectivity over the other related metalloenzymes.
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  42. A12980
    RN-18

    HIV-1 Vif inhibitor

    RN-18 is a HIV-1 viral infectivity factor (HIV-1 Vif) inhibitor with an IC50 of 6 μM in nonpermissive H9 cells.
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  43. A12997
    Vidofludimus (4SC-101)

    DHODH inhibitor

    Vidofludimus is a novel orally active and potent DHODH inhibitor.
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  44. A13026
    Prodipine hydrochloride
    Prodipine, a diphenyl-phosphonate derivative. The IC50s of Prodipine for purified and plasma Dipeptidyl peptidase IV (DPP IV) from the rabbit are 4.5 μM and 30 μM, respectively.
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  45. A13049
    Tautomycetin

    PP1 inhibitor

    Tautomycetin induces apoptosis by inactivating Akt through a PP1-independent signaling pathway in human breast cancer cells.
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  46. A13083
    Tolrestat

    aldose reductase inhibitor

    Tolrestat is an aldose reductase inhibitor[1] which was approved for the control of certain diabetic complications.
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  47. A13105
    Setrobuvir (ANA-598)

    HCV Polymerase Inhibitor

    Setrobuvir (ANA-598) is a direct-acting antiviral or DAA, is a non-nucleoside inhibitor of the HCV RNA polymerase
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  48. A13118
    Celgosivir

    alpha-glucosidase I inhibitor

    Celgosivir is an alpha-glucosidase I inhibitor for the potential treatment of HCV infection.
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  49. A13183
    Trifloxystrobin
    Trifloxystrobin (CGA 279202) is a fungicide, with EC50s of 23.0 μg/L and 1.7 μg/L for Daphnia magna neonate and embryos, respectively, after treatment for 48 h.
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  50. A13185
    MMP3 inhibitor 1

    MMP-3 inhibitor

    MMP3 inhibitor 1 is a potent and highly selective MMP-3 inhibitor with an IC50 of 1 nM.
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  1. Inhibitor 1109items
  2. Antagonist 3items
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  4. Modulator 12items
  5. Inducer 2items
  6. Substrate 5items
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  1. Akt2 1item
  2. Akt3 1item